1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. PKA
    Phosphodiesterase (PDE)
  3. Sp-cAMPS

Sp-cAMPS 

Cat. No.: HY-100530B
Handling Instructions

Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA IPKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM.

For research use only. We do not sell to patients.

Sp-cAMPS Chemical Structure

Sp-cAMPS Chemical Structure

CAS No. : 71774-13-5

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Description

Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA IPKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].

IC50 & Target[2][3]

PKA I

 

PKA II

 

PDE3A

47.6 μM (Ki)

PDE10 GAF domain

50 μM (EC50)

In Vitro

Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca2+ can be mimicked by Sp-cAMPS[4].

In Vivo

In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals[5].

Molecular Weight

345.27

Formula

C₁₀H₁₂N₅O₅PS

CAS No.

71774-13-5

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]@]2([H])[[email protected]@]1([H])O[[email protected]](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sp-cAMPSPKAPhosphodiesterase (PDE)Protein kinase APDE3AcAMPPKA IPKA IIPDE10Ca2+glucagonmemoryInhibitorinhibitorinhibit

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Sp-cAMPS
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