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  6. (S)-(-)-Tetrahydroberberine

(S)-(-)-Tetrahydroberberine  (Synonyms: (-)-Canadine; (S)-(-)-Canadine)

Cat. No.: HY-N1418
Handling Instructions Technical Support

(S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity.

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(S)-(-)-Tetrahydroberberine

(S)-(-)-Tetrahydroberberine 화학구조

CAS No. : 5096-57-1

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg   견적 받기  
50 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of (S)-(-)-Tetrahydroberberine:

(S)-(-)-Tetrahydroberberine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

(S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
5.4 μM
Compound: 3
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assa
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assa
[PMID: 27709945]
KB IC50
>734 μM
Compound: Canadine
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 11141105]
MRC5 CC50
125 μM
Compound: 9
Cytotoxicity against MRC5 cells
Cytotoxicity against MRC5 cells
[PMID: 17239594]
MRC5 IC50
12 μM
Compound: 9
Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
[PMID: 17239594]
분자량

339.39

화학식

C20H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C[C@]23[H])C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

Acetone : ≥ 12.5 mg/mL (36.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9465 mL 14.7323 mL 29.4646 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Acetone 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL
10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL
15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL
20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL
25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL
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(S)-(-)-Tetrahydroberberine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(-)-Tetrahydroberberine5096-57-1(-)-Canadine (S)-(-)-CanadineOthersInhibitorinhibitorinhibit

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상품명:
(S)-(-)-Tetrahydroberberine
Cat. No.:
HY-N1418
수량:
MCE Japan Authorized Agent:

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