Santalene  (Synonyms: α-Santalene)

Santalene is a bicyclic sesquiterpene and a major component of sandalwood oil found in the heartwood of Santalum album. Santalene exhibits antibacterial, antioxidant and antitumor pharmacological activities^[1].

Santalene in engineered Komagataella phaffii STE-1, with a single copy of TEF1p-driven SAS, produces α-santalene at a titer of 90.2 mg/L in shake flask two-phase fermentation, with no observed cytotoxicity or metabolic burden^[1].
Santalene (20 g/L peptone additives) in Komagataella phaffii STE-9 cultured in YP1D medium (with peptone P1) increases α-santalene production to a titer of 829.8 mg/L in shake flask two-phase fermentation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

204.35

C₁₅H₂₄

512-61-8

Liquid (Density: 0.9075 g/cm³)

Colorless to light yellow

C[C@]12[C@@H](C3)[C@@]1([H])CC3[C@@](C)2CC/C=C(C)/C

Room temperature in continental US; may vary elsewhere.

• [1]. Yimeng Zuo, et al. Establishing Komagataella phaffii as a Cell Factory for Efficient Production of Sesquiterpenoid α-Santalene. J. Agric. Food Chem. 2022, 70, 8024−8031