2. GPCR/G Protein
  3. CRFR
  4. Sauvagine

Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases.

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Custom Peptide Synthesis

Sauvagine

Sauvagine 화학구조

CAS No. : 74434-59-6

사이즈 재고
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100 mg   견적 받기  
250 mg   견적 받기  

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Other Forms of Sauvagine:

Sauvagine Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases[1][2][3].

In Vitro

Sauvagine (0.001-1000 nM; 20 min) potently stimulates intracellular cAMP accumulation in HM-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.1 nM[1].
Sauvagine (0.001-100 nM; 20 min) stimulates intracellular cAMP accumulation in PC-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sauvagine Related Antibodies
In Vivo

Sauvagine (i.c.v or i.c. or i.v.; single dose) elevates plasma ACTH, catecholamine and glucose concentrations in rats[2].
Sauvagine (i.v.; single dose) increases superior mesenteric artery flow and plasma glucose, and decrease mean arterial pressure in conscious dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

4599.31

화학식

C202H346N56O63S
CAS No.
Sequence

{Pry}-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
Sequence Shortening

{Pry}GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
용액&용해도
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
순도&문서
References
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Sauvagine Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sauvagine74434-59-6CRFRCorticotropin-releasing Factor ReceptorCRHRHM-CRF receptorPC-CRF receptorACTH293-EBNA cellsα-helical CRF-(9-41)CV-1 cellscorticotropin-releasing factorhypothalamic-pituitary-adrenal axisβ-endorphinintracellular cAMPInhibitorinhibitorinhibit

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상품명:
Sauvagine
Cat. No.:
HY-P1298
수량:
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