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α-Topoisomerase II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Casein Kinase (1) Drug Intermediate (1) EGFR (1) Microtubule/Tubulin (1) Topoisomerase (1) VEGFR (1)
By Research Areas:	Cancer (2) Infection (1)

Inhibitors & Agonists

Antibodies

Targets Recommended: Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-59024

δ-Carboline	Drug Intermediate	Infection Cancer
δ-Carboline is a nitrogen-containing heterocyclic compound, and its derivatives all exhibit anti-cancer and antibacterial activities .

HY-146138

EGFR-IN-57	EGFR VEGFR Casein Kinase Topoisomerase Microtubule/Tubulin Apoptosis	Cancer
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC₅₀ of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, *CK2α, topoisomerase* IIβ and tubulin polymerization with IC₅₀ values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) IP (2) WB (3) ELISA (1)
Isotype:	IgG (2) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80980

	Topoisomerase II alpha Antibody (YA3544) DNA Topoisomerase II; DNA Topoisomerase II-alpha; TOP2; TP2A; alpha isozyme, Topoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P80980A

	Topoisomerase II alpha Antibody (YA3544)(PBS only) DNA Topoisomerase II; DNA Topoisomerase II-alpha; TOP2; TP2A; alpha isozyme, Topoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P85929

	Topoisomerase II alpha Antibody (YA5621) alpha isozyme; ATP hydrolyzing DNA Topoisomerase II alfa; DNA gyrase; DNA Topoisomerase; ATP hydrolyzing; DNA Topoisomerase 2 alpha; DNA Topoisomerase 2-alpha; DNA Topoisomerase II 170 kD; DNA Topoisomerase II alpha isozyme; DNA Topoisomerase II; DNA Topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; Topoisomerase DNA II alpha 170 kDa; TP2A	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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