EGFR-IN-57
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2492382-37-1
- Formula: C22H15N3O2S
- Molecular Weight:385.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
EGFR 0.054 μM (IC50) |
VEGFR-2 0.087 μM (IC50) |
topoisomerase II beta 0.13 μM (IC50) |
CK2α 0.171 μM (IC50) |
tubulin polymerization 3.16 μM (IC50) |
Chemical Information
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CAS No. 2492382-37-1
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Molecular Weight 385.44
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Formula C22H15N3O2S
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SMILES
O=C1N=C(NC2=NOC(C)=C2)S/C1=C\C3=C4C=CC=CC4=CC5=CC=CC=C35
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-57 Related Classifications
HY-146138 Related Classifications
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