2492382-37-1
Chemical Structure
EGFR-IN-57
- CAS No.: 2492382-37-1
- Formula:C22H15N3O2S
- Molecular Weight:385.44
IUPAC Name: (Z)-5-(anthracen-9-ylmethylene)-2-((5-methylisoxazol-3-yl)amino)thiazol-4(5H)-one
InChIKey: BEJMCFWWVSSWOF-UNOMPAQXSA-N
SMILES: O=C1N=C(NC2=NOC(C)=C2)S/C1=C\C3=C4C=CC=CC4=CC5=CC=CC=C35
Biological Activity: EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis[1].
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EGFR-IN-57 | EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis. | |||||||||||||||||||||
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Keywords
