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Results for "

α1A/α1a-adrenergic receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adenosine Receptor (2) Adrenergic Receptor (20) Apoptosis (2) Bacterial (2) Drug Isomer (1) Drug Metabolite (1) Isotope-Labeled Compounds (1) Reference Standards (5)
By Research Areas:	Cancer (3) Cardiovascular Disease (8) Endocrinology (9) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (9)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10122

Silodosin 5 Publications Verification KAD 3213; KMD 3213	Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active **α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i** values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-101300

Cirazoline hydrochloride LD 3098 hydrochloride	Adenosine Receptor	Neurological Disease
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full **α1A-adrenergic receptor (α1A-AR) agonist (K_i=120 nM) and only a partial agonist at α1B-AR (K_i= 960 nM) and α1D-AR (K_i**=660 nM) .

HY-B1435

Moxisylyte hydrochloride Thymoxamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) hydrochloride is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy .

HY-117071

Dabuzalgron Ro 115-1240	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) is an orally active and selective **α-1A adrenergic receptor** agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-101366

A-61603	Adrenergic Receptor	Endocrinology
A-61603 is a selective **α₁A/α₁a-adrenergic receptor agonist with K_i** of 8.89 nM for rat submaxillary gland α1A, K_i of 30.5 nM for cloned bovine α1a. A-61603 potentiates Ca ²⁺ transients with EC₅₀ of 6.9 nM. A-61603 stimulates phosphoinositide hydrolysis, induces contractile responses in vas deferens, prostate strips, and spleen strips, and exhibits low activity in aortic rings. A-61603 can be used for research on adrenergic function .

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

HY-101755

Tedatioxetine hydrobromide Lu AA24530 hydrobromide	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist . ,

HY-W103372

Vasorelaxant agent-2	Adrenergic Receptor	Cardiovascular Disease
Vasorelaxant agent-2 (Compound 8h) targets **α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC₅₀** of 0.79 μM .

HY-123044

Tedatioxetine Lu AA24530	5-HT Receptor Adrenergic Receptor	Neurological Disease
Tedatioxetine (Lu AA24530) acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human **α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor** and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel **α₁-Adrenergic Receptor** subtype-selective drugs .

HY-145480

Silodosin Glucuronide sodium Silodosin β-D-glucuronide sodium	Drug Metabolite	Others
Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for **α1A-adrenergic receptor** (α1A-AR) with K_i of 0.036 nM .

HY-B1435A

Moxisylyte Thymoxamine	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte competitively antagonizes the activation mediated by norepinephrine. Moxisylyte relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte is applicable to research related to erectile dysfunction and multiple system atrophy .

HY-10122S

Silodosin-d4	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology Cancer
Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-10122R

Silodosin (Standard) KAD 3213 (Standard); KMD 3213 (Standard)	Reference Standards Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (Standard) is the analytical standard of Silodosin. This product is intended for research and analytical applications. Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active **α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i** values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-U00237B

L-771688 hydrochloride	Adrenergic Receptor	Others
L-771688 hydrochloride is a potent and highly selective α1A-adrenoceptor antagonist (Kd=43-90 pM). L-771688 hydrochloride is effective against cloned human, rat and dog α1A-adrenergic receptors. L-771688 exhibits high affinity (Ki ≤ 1 nM) and over 500-fold selectivity over the α1B and α1D isoforms. L-771688 potently antagonizes norepinephrine-induced responses at these receptors. Inhibits contractions induced by phenylephrine or A-61603 in rat, dog, human and monkey models .

HY-103202

SNAP5089 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
SNAP5089 (hydrochloride) is a selective **α1A adrenergic receptor** antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia .

HY-117071A

Dabuzalgron hydrochloride Ro 115-1240 hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective **α-1A adrenergic receptor** agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-183177

Zolertine	Adrenergic Receptor	Cardiovascular Disease
Zolertine is an α-adrenergic receptor antagonist, with a pK_i of 6.35 for rabbit α₁A-adrenergic receptor and a pK_i of 6.81 for rat α₁B-adrenergic receptor. Zolertine competitively blocks α₁D-adrenergic receptor-mediated vasoconstriction and α₁A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension .

HY-101300R

Cirazoline hydrochloride (Standard) LD 3098 hydrochloride (Standard)	Reference Standards Adenosine Receptor	Neurological Disease
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) .

HY-10122A

(Rac)-Silodosin (Rac)-KAD 3213; (Rac)-KMD 3213	Adrenergic Receptor	Endocrinology
(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker .

HY-B1435R

Moxisylyte hydrochloride (Standard) Thymoxamine hydrochloride (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) hydrochloride Standard is the analytical standard of Moxisylyte hydrochloride (HY-B1435). This product is intended for research and analytical applications. Moxisylyte (Thymoxamine) hydrochloride is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy.

HY-101755R

Tedatioxetine hydrobromide (Standard) Lu AA24530 hydrobromide (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Tedatioxetine hydrobromide (Standard) (Lu AA24530 hydrobromide (Standard)) is the analytical standard of Tedatioxetine hydrobromide (HY-101755). This product is intended for research and analytical applications. Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist . ,

HY-W783844

(R)-Nantenine	Drug Isomer	Neurological Disease
(R)-Nantenine ((R)-(-)-nantenine) is the levorotatory isomer of Nantenine (HY-N9141). (R)-Nantenine has high affinity and selectivity for the **α1A adrenergic receptor**. (R)-Nantenine can block the behavioral suppression induced by MDMA. (R)-Nantenine is mainly used for the research related to diseases caused by MDMA abuse .

HY-106954R

Upidosin (Standard) Rec 15/2739 (Standard); Recordati 15/2739 (Standard); SB 216469 (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology
Upidosin (Standard) (Rec 15/2739 (Standard)) is the analytical standard of Upidosin (HY-106954). This product is intended for research and analytical applications. Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

Cat. No.	Product Name	Target	Research Area

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human **α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor** and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel **α₁-Adrenergic Receptor** subtype-selective drugs .

Cat. No.	Product Name	Chemical Structure

HY-10122S

Silodosin-d4
Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

Silodosin-d4

Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82314

	alpha 1a Adrenergic Receptor Antibody (YA2059) ADRA1A; ADRA1C; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	alpha 1a Adrenergic Receptor Antibody (YA2059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1a Adrenergic Receptor.

HY-P82314A

	alpha 1a Adrenergic Receptor Antibody (YA2059)(PBS only) ADRA1A; ADRA1C; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	alpha 1a Adrenergic Receptor Antibody (YA2059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1a Adrenergic Receptor.

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