1. GPCR/G Protein
  2. Adenosine Receptor
  3. Cirazoline hydrochloride

Cirazoline hydrochloride (Synonyms: LD 3098 hydrochloride)

Cat. No.: HY-101300
Handling Instructions

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).

For research use only. We do not sell to patients.

Cirazoline hydrochloride Chemical Structure

Cirazoline hydrochloride Chemical Structure

CAS No. : 40600-13-3

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].

In Vitro

Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1].

Cell Viability Assay[1]

Cell Line: Glioblastoma‐initiating cells
Concentration: 5 μM; 10 μM
Incubation Time: 24 hours
Result: Did not effect GIC cell survival.
In Vivo

Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1].

Animal Model: B6/CBA mice[1]
Dosage: 40 μM
Administration: Drinking water; 40 μM; 9 month
Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice .
Molecular Weight

252.74

Formula

C₁₃H₁₇ClN₂O

CAS No.

40600-13-3

SMILES

[H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CirazolineLD 3098LD3098LD-3098Adenosine ReceptorP1 receptorobsessivecompulsivedisorderantidepressantFST glioblastoma‐initiatingcellsGICsCHOInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Cirazoline hydrochloride
Cat. No.:
HY-101300
Quantity:
MCE Japan Authorized Agent: