Cirazoline hydrochloride
Based on 1 Customer Validation
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 40600-13-3
- Formula: C13H17ClN2O
- Molecular Weight:252.74
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin-induced GIC death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Glioblastoma‐initiating cells
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Concentration:5 μM; 10 μM
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Incubation Time:24 hours
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Result:Did not effect GIC cell survival.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6/CBA mice[1]
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Dosage:40 μM
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Administration:Drinking water; 40 μM; 9 month
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Result:Reversed antidepressant-like phenotype of CAM α1A-AR Mice .
Chemical Information
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CAS No. 40600-13-3
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Appearance Solid
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Molecular Weight 252.74
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Formula C13H17ClN2O
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Color White to off-white
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SMILES
[H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1
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Synonyms
LD 3098 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 33.33 mg/mL (131.87 mM; Need ultrasonic)
DMSO : 12.5 mg/mL (49.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Doze VA, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57. [Content Brief]
[2]. Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8(5):511-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.9566 mL | 19.7832 mL | 39.5664 mL | 98.9159 mL |
| 5 mM | 0.7913 mL | 3.9566 mL | 7.9133 mL | 19.7832 mL | |
| 10 mM | 0.3957 mL | 1.9783 mL | 3.9566 mL | 9.8916 mL | |
| 15 mM | 0.2638 mL | 1.3189 mL | 2.6378 mL | 6.5944 mL | |
| 20 mM | 0.1978 mL | 0.9892 mL | 1.9783 mL | 4.9458 mL | |
| 25 mM | 0.1583 mL | 0.7913 mL | 1.5827 mL | 3.9566 mL | |
| 30 mM | 0.1319 mL | 0.6594 mL | 1.3189 mL | 3.2972 mL | |
| 40 mM | 0.0989 mL | 0.4946 mL | 0.9892 mL | 2.4729 mL | |
| H2O | 50 mM | 0.0791 mL | 0.3957 mL | 0.7913 mL | 1.9783 mL |
| 60 mM | 0.0659 mL | 0.3297 mL | 0.6594 mL | 1.6486 mL | |
| 80 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2364 mL | |
| 100 mM | 0.0396 mL | 0.1978 mL | 0.3957 mL | 0.9892 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cirazoline hydrochloride Related Classifications
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