2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Zolertine

Zolertine is an α-adrenergic receptor antagonist, with a pKi of 6.35 for rabbit α1A-adrenergic receptor and a pKi of 6.81 for rat α1B-adrenergic receptor. Zolertine competitively blocks α1D-adrenergic receptor-mediated vasoconstriction and α1A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension.

For research use only. We do not sell to patients.

Zolertine

Zolertine Chemical Structure

CAS No. : 4004-94-8

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Zolertine Related Antibodies

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Description

Zolertine is an α-adrenergic receptor antagonist, with a pKi of 6.35 for rabbit α1A-adrenergic receptor and a pKi of 6.81 for rat α1B-adrenergic receptor. Zolertine competitively blocks α1D-adrenergic receptor-mediated vasoconstriction and α1A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension[1].

IC50 & Target[1]

α1A-adrenergic receptor

6.35 (pKi)

α1B-adrenergic receptor

6.81 (pKi)

In Vitro

Zolertine (30 min) competes for the α1-adrenergic receptor binding sites on rat liver (α1B) and rabbit liver (α1A) cell membranes, with pKi values of 6.81 and 6.35, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zolertine Related Antibodies
In Vivo

Zolertine appears to exert an antihypertensive effect by reducing blood pressure in Mecamylamine (HY-B1395A)-induced hypertensive dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

258.32

Formula

C13H18N6
CAS No.
SMILES

C1(CCN2CCN(CC2)C3=CC=CC=C3)=NN=NN1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zolertine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zolertine4004-94-8Adrenergic ReceptorBeta Receptorvasoconstrictionnoradrenalineα1-adrenoceptorhypertensionα1D-adrenoceptorsrat α1B-adrenoceptorrat liverhypertensive dogsrabbit liverrabbit α1A-adrenoceptorInhibitorinhibitorinhibit

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