Dabuzalgron hydrochloride (Synonyms: Ro 115-1240 hydrochloride)

Cat. No.: HY-117071A Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function.

For research use only. We do not sell to patients.

Dabuzalgron hydrochloride Chemical Structure

CAS No. : 219311-43-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of Dabuzalgron hydrochloride:

Dabuzalgron In-stock

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

354.25

Formula

C₁₂H₁₇Cl₂N₃O₃S

CAS No.

219311-43-0

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=C(C=CC(OCC2=NCCN2)=C1C)Cl)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (141.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8229 mL	14.1143 mL	28.2287 mL
5 mM	0.5646 mL	2.8229 mL	5.6457 mL
10 mM	0.2823 mL	1.4114 mL	2.8229 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (251 KB) HNMR (345 KB) RP-HPLC (258 KB) MS (73 KB)

Handling Instructions (2659 KB)

References

[1]. Beak J, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb;2(1):39-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8229 mL	14.1143 mL	28.2287 mL	70.5716 mL
	5 mM	0.5646 mL	2.8229 mL	5.6457 mL	14.1143 mL
	10 mM	0.2823 mL	1.4114 mL	2.8229 mL	7.0572 mL
	15 mM	0.1882 mL	0.9410 mL	1.8819 mL	4.7048 mL
	20 mM	0.1411 mL	0.7057 mL	1.4114 mL	3.5286 mL
	25 mM	0.1129 mL	0.5646 mL	1.1291 mL	2.8229 mL
	30 mM	0.0941 mL	0.4705 mL	0.9410 mL	2.3524 mL
	40 mM	0.0706 mL	0.3529 mL	0.7057 mL	1.7643 mL
	50 mM	0.0565 mL	0.2823 mL	0.5646 mL	1.4114 mL
	60 mM	0.0470 mL	0.2352 mL	0.4705 mL	1.1762 mL
	80 mM	0.0353 mL	0.1764 mL	0.3529 mL	0.8821 mL
	100 mM	0.0282 mL	0.1411 mL	0.2823 mL	0.7057 mL

Dabuzalgron hydrochloride Related Classifications

Endocrinology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dabuzalgron219311-43-0Ro 115-1240Adrenergic ReceptorApoptosisBeta ReceptorCelldeathapoptosismitochondrialmembranepotentialurinaryincontinenceInhibitorinhibitorinhibit

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