Urinary Incontinence

Female urinary incontinence is a prevalent condition, particularly among elderly women, characterized by the involuntary leakage of urine, with prevalence rates ranging from 15% to 55% depending on age and population. It significantly impacts physical health, mental well-being, and social functioning, leading to reduced quality of life. The condition can be classified into stress urinary incontinence (SUI), urge urinary incontinence (UUI), and mixed urinary incontinence (MUI), with similar types and impact observed in male patients, where prevalence reaches 11% in men aged 60–64 and increases to 31% in those aged 85 and older.

References:

[1]. Female Urinary Incontinence. sciencedirect.

Urinary Incontinence (3):

Targets:	P2X Receptor (1) Calcium Channel (1) mAChR (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-182715

PSB-10211	66295-57-6
PSB-10211 is a P2X2 receptor antagonist with an IC₅₀ of 0.086 μM against rat P2X2 receptors. PSB-10211 inhibits ATP-mediated currents of rat P2X2 receptors expressed in Xenopus oocytes. PSB-10211 can be used in studies related to pain and urinary incontinence.

HY-182599

RCC-36 hydrochloride	129927-37-3
RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K⁺ currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity.

HY-129518

Phenamacide hydrochloride	31031-74-0
Phenamacide hydrochloride is an anti-spasmodic agent that can be used for the study of urinary incontinence.

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