RCC-36 hydrochloride

RCC-36 (10 μM; 5 min) hydrochloride inhibits L-type calcium currents in isolated guinea pig detrusor smooth muscle cells in vitro in a voltage- and concentration-dependent manner, with an IC₅₀ of 6.4 µM at a holding potential of -60 mV and 1.2 µM at -40 mV, and decreases the calcium window current by shifting steady-state inactivation curves hyperpolarizingly without altering activation curves^[1].
RCC-36 (1-100 µM) hydrochloride potently inhibits L-type Ca²⁺ currents in isolated guinea pig ventricular myocytes with an IC₅₀ of 27.0 µM^[2].
RCC-36 (10 nM-3 μM; at least 30 minutes) hydrochloride exhibits competitive anticholinergic activity on isolated human detrusor smooth muscle, with a pA₂ value of 7.20, and suppresses the maximum acetylcholine-induced contraction at 3 μM^[3].
RCC-36 (1 μM-1 mM; at least 30 minutes) hydrochloride inhibits 80 mM KCl-induced contractions in isolated human detrusor smooth muscle with a maximum inhibition of 87.1% and an IC₅₀ of 13.0 μM^[3].
RCC-36 (100 nM-1 mM; at least 30 minutes) hydrochloride potently inhibits 5 mM CaCl₂-induced contractions in isolated human detrusor smooth muscle with a maximum inhibition of 98.5% and an IC₅₀ of 1.34 μM^[3].
RCC-36 (1 nM-200 μM; at least 30 minutes) hydrochloride inhibits electric field-induced contractions in isolated human detrusor smooth muscle with a maximum inhibition of 81.1% and an IC₅₀ of 2653 μM^[3].
RCC-36 (10 nM-300 μM; at least 30 minutes) hydrochloride potently inhibits Atropine (HY-B1205)-resistant electric field-induced contractions in isolated human detrusor smooth muscle with a maximum inhibition of 82.3% and an IC₅₀ of 2.65 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.