129927-37-3
Chemical Structure
RCC-36 hydrochloride
- CAS No.: 129927-37-3
- Formula:C22H32ClNO3
- Molecular Weight:393.95
InChIKey: AEPBOUHKRSABGU-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OC(C)(C)C#CCNCC.Cl
Biological Activity: RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K+ currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity[1][2][3].
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RCC-36 hydrochloride | RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K+ currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity. | |||||||||||||||||||||
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References
- [1]. Hayashi S, et al. Inhibitory effects of NS-21, a novel drug for urinary incontinence, and its active metabolite, RCC-36, on L-type calcium currents in isolated guinea pig detrusor smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 1997;355(5):659-666. [Content Brief]
- [2]. Hayashi S, et al. Cardiac electrophysiological actions of NS-21 and its active metabolite, RCC-36, compared with terodiline. Naunyn Schmiedebergs Arch Pharmacol. 1997;355(5):651-658. [Content Brief]
- [3]. Kikukawa H, et al. Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle. Int J Urol. 1998;5(3):268-275. [Content Brief]
