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Cat. No.: HY-W1058741

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α1A Adrenoceptor agonist-1

α1A Adrenoceptor agonist-1 (compound 13) is an α₁A adrenoceptor (α₁A adrenoceptor) agonist with an EC₅₀ of 385 nM for α1A. α1A Adrenoceptor agonist-1 exhibits in vitro functional agonistic activity targeting adrenoceptors. α1A Adrenoceptor agonist-1 can be used for the research of stress urinary incontinence.

For research use only. We do not sell to patients.

CAS No.: 945389-41-3
Formula: C₁₃H₁₄N₂
Molecular Weight:198.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α1A Adrenoceptor agonist-1 Chemical Structure

CAS No.: 945389-41-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

α1A-adrenergic receptor

385 nM (EC₅₀)

α1B-adrenergic receptor

791 nM (EC₅₀)

α1D-adrenergic receptor

364 nM (EC₅₀)

α2A Adrenergic Receptor

722 nM (EC₅₀)

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	385 nM Compound: 13	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	[PMID: 18400496]
CHO	EC₅₀	791 nM Compound: 13	Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	[PMID: 18400496]
CHO	EC₅₀	364 nM Compound: 13	Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	[PMID: 18400496]
CHO-K1	EC₅₀	722 nM Compound: 13	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	[PMID: 18400496]

In Vitro

α₁A Adrenoceptor agonist-1 (compound 13) acts as a partial agonist at human α₁A, α₁B, α₁D, and α₂A adrenoceptors, with an α₁A EC₅₀ of 385 nM and an α₁A Emax of 71%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 945389-41-3
Molecular Weight 198.26
Formula C₁₃H₁₄N₂
SMILES

C1(C2C3=C(CCC2)C=CC=C3)=NC=CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Whitlock GA, et al. Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists. Bioorganic & Medicinal Chemistry Letters. 2008;18:2930-2934. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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