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Cat. No.: HY-10122A

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(Rac)-Silodosin

Name: (Rac)-Silodosin
Brand: MedChemExpress
SKU: HY-10122A
Availability: PreOrder

(Synonyms: (Rac)-KAD 3213; (Rac)-KMD 3213)

(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker.

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CAS No.: 160970-64-9
화학식: C₂₅H₃₂F₃N₃O₄
분자량:495.53

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

(Rac)-Silodosin Chemical Structure

CAS No.: 160970-64-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker^[1].

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	13.4 nM Compound: 14i	Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	[PMID: 27031406]
HEK293	IC₅₀	263.9 nM Compound: 14i	Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	[PMID: 27031406]
HEK293	IC₅₀	3.2 nM Compound: 14i	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	[PMID: 27031406]

Chemical Information

CAS No. 160970-64-9
Appearance Solid
분자량 495.53
화학식 C₂₅H₃₂F₃N₃O₄
Color White to off-white
SMILES

O=C(C1=CC(CC(NCCOC2=CC=CC=C2OCC(F)(F)F)C)=CC3=C1N(CCCO)CC3)N
Synonyms

(Rac)-KAD 3213; (Rac)-KMD 3213
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao F, et, al. Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists. J Med Chem. 2016 Apr 28;59(8):3826-39. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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