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AGT

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By Targets:	Angiotensin Receptor (1) Apoptosis (2) DNA/RNA Synthesis (1) HCV (1) Insulin Receptor (1) PKC (1) Small Interfering RNA (siRNA) (1) Toll-like Receptor (TLR) (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (2)

11

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

4

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a brain penetrating recombinant fusion protein of a chimeric monoclonal antibody against the human insulin receptor (HIR) and human iduronidase (IDUA). Valanafusp alfa can be used for the research of Mucopolysaccharidosis type I (MPS I) .

O6-Benzylguanine 1 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase *(MGMT/AGT)* inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

ODN 20844	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

AGT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AGT Human Pre-designed siRNA Set A contains three designed siRNAs for AGT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AGT Human Pre-designed siRNA Set A AGT Human Pre-designed siRNA Set A

Angiotensinogen (1-13) (human)	Angiotensin Receptor	Cardiovascular Disease
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .

ODN 24888	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant .

ODN 105870	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research .

ODN 105871	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105871 can be uesd for inflammatory immune responses research .

Aprinocarsen sodium ISIS 3521 sodium	PKC	Cancer
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

Custirsen OGX-011	Apoptosis	Cancer
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

Mipomersen sodium ISIS 301012	HCV	Metabolic Disease
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

Cat. No.	Product Name	Target	Research Area

Angiotensinogen (1-13) (human)	Angiotensin Receptor	Cardiovascular Disease
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .

Cat. No.	Product Name	Target	Research Area

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a brain penetrating recombinant fusion protein of a chimeric monoclonal antibody against the human insulin receptor (HIR) and human iduronidase (IDUA). Valanafusp alfa can be used for the research of Mucopolysaccharidosis type I (MPS I) .

Species:	Human (2) Mouse (1) Rat (1)
Tag:	His (4)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

	Serpin A8/Angiotensinogen Protein, Human (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Human	HEK293
	Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is 452 a.a., with molecular weight of 52-64 kDa.

	Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Mouse	HEK293
	Serpin A8 (or angiotensinogen) is an important regulator in the renin-angiotensin system, fine-tuning blood pressure and electrolyte balance. This multifunctional protein acts as a potent vasoconstrictor, affecting vascular smooth muscle and affecting cardiac function via the sympathetic nervous system. Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is 453 a.a., with molecular weight of ~58 kDa.

	Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Rat	HEK293
	Serpin A8 (or angiotensinogen) is a key regulator of the renin-angiotensin system, affecting blood pressure, fluid and electrolyte balance. As a vasoconstrictor, it directly affects vascular smooth muscle and affects myocardial contractility and heart rate through the sympathetic nervous system. Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is 453 a.a., with molecular weight of 58-75 kDa.

	Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) Angiotensinogen; Serpin A8; AGT and SERPINA8	Human	HEK293
	Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is 452 a.a., with molecular weight of 55.0-72.27 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P82352

Angiotensinogen Antibody (YA2097)

Angiotensinogen; Serpin A8; AGT; SERPINA8; Des-Asp[1]-angiotensin II; Serine (or cysteine) proteinase inhibitor
WB, IHC-P, IP Mouse
HY-P82275

AGXT Antibody (YA2020)

AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1
WB Mouse, Rat

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