2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Angiotensinogen Antibody (YA2097)

Angiotensinogen Antibody (YA2097)

Cat. No.: HY-P82352
COA
SDS
User Guide for Antibodies Technical Support

Angiotensinogen Antibody (YA2097) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensinogen.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

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  • Descripciòn

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Descripciòn

Angiotensinogen Antibody (YA2097) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensinogen.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Peso molecular
Predicted band size: 52 kDa;
Observed band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse
SwissProt ID
Gene ID
Immunogen

Recombinant protein of mouse Angiotensinogen full length.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Verification Image
WB

  • Western blot analysis of extracts from Mouse Brain (lane 2(20μg)) and Mouse Heart (lane 3(10μg)) using Angiotensinogen Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background
Function：Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor; Stimulates aldosterone release; Is a ligand for the G-protein coupled receptor MAS1 (PubMed:12829792). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (PubMed:12829792, PubMed:18026570)
Subcellular Localization：Secreted
RRID
Database

Entrez Gene: 11606 Mouse

SwissProt: P11859 Mouse

Research Field

Cardiovascular
Synonyms
Angiotensinogen; Serpin A8; AGT; SERPINA8; Des-Asp[1]-angiotensin II; Serine (or cysteine) proteinase inhibitor
Documentación
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
Referencias

Angiotensinogen Antibody (YA2097) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
Angiotensinogen Antibody (YA2097)
Cat. No.:
HY-P82352
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