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Adipose triglyceride lipase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATGL (5) MAGL (1) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (1) MNK (1) PPAR (1) Stearoyl-CoA Desaturase (SCD) (1)
By Research Areas:	Cancer (1) Metabolic Disease (5)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: ATGL Lipase Microsomal Triglyceride Transfer Protein (MTP) DAGL MAGL Hormone-Sensitive Lipase (HSL)

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-15859

Atglistatin 35+ Cited Publications	ATGL	Metabolic Disease
Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor which inhibits lipolysis with an IC₅₀ of 0.7 μM in vitro.

HY-148756

NG-497 3 Publications Verification	ATGL	Cancer
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research .

HY-E70277

Hexadecyl-CoA	ATGL	Metabolic Disease
Hexadecyl-CoA is a thioether analog of acyl-CoA that can inhibit adipose triglyceride lipase (ATGL) .

HY-111952

SR-4995 CID 16016685	Endogenous Metabolite	Others
SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways.

HY-111953

SR-4559	MAGL ATGL	Metabolic Disease
SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research .

HY-15859R

Atglistatin (Standard)	ATGL	Metabolic Disease
Atglistatin (Standard) is the analytical standard of Atglistatin. This product is intended for research and analytical applications. Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor which inhibits lipolysis with an IC50 of 0.7 μM in vitro.

HY-182046

HD202A	MNK PPAR Eukaryotic Initiation Factor (eIF) Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC₅₀ values of 6.09 nM and 8.06 nM, and K_d values of 1.913 μM and 5.244 μM, respectively) that inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. HD202A effectively suppresses body weight gain, hepatic lipid accumulation and elevation of serum lipids, significantly improves glucose tolerance and insulin sensitivity of the organism, and ameliorates inflammatory features. With these comprehensive pharmacological activities, HD202A exhibits great application potential in studies of metabolic dysfunction-associated steatotic liver disease .

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HY-P71600

	PNPLA2 Protein, Human (His-SUMO) 1110001C14Rik ; Adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; Desnutrin; EC 3.1.1.3; FP17548; IPLA2 zeta; IPLA2-zeta; PEDF R; Pigment epithelium derived factor; Pigment epithelium-derived factor; plpl; plpl2; PLPL2_HUMAN; Pnpla2; Transport secretion protein 2; Transport secretion protein 2.2; Transport-secretion protein 2; triglyceride hydrolase ; TTS 2.2; TTS2; TTS2.2; ZETA	Human	E. coli
	The PNPLA2 protein catalyzes the hydrolysis of triglycerides, preferably long-chain fatty acid esters, in lipid droplets. PNPLA2 Protein, Human (His-SUMO) is the recombinant human-derived PNPLA2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (1) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P86317

	Adipose Triglyceride Lipase Antibody (YA6009)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Adipose Triglyceride Lipase Antibody (YA6009) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adipose Triglyceride Lipase.

HY-P80533

	Adipose Triglyceride Lipase Antibody (YA637) 1 Publications Verification ATGL; Desnutrin; plpl; plpl2; Pnpla2; TTS 2.2; TTS2; TTS2.2; ZETA	WB	Human, Mouse, Rat
	Adipose Triglyceride Lipase Antibody (YA637) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adipose Triglyceride Lipase.

HY-P80533A

	Adipose Triglyceride Lipase Antibody (YA637)(PBS only) ATGL; Desnutrin; plpl; plpl2; Pnpla2; TTS 2.2; TTS2; TTS2.2; ZETA	WB	Human, Mouse, Rat
	Adipose Triglyceride Lipase Antibody (YA637) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adipose Triglyceride Lipase.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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