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Angiotensin+Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (6) Apelin Receptor (APJ) (1) Apoptosis (2) Natriuretic Peptide Receptor (NPR) (1) Neprilysin (1) NF-κB (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (6) Endocrinology (3) Inflammation/Immunology (2) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18204A

Sacubitril/Valsartan 5+ Cited Publications LCZ696	Angiotensin Receptor Neprilysin Apoptosis	Cardiovascular Disease Endocrinology Cancer
Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure . Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis .

HY-B0780

Fimasartan 4 Publications Verification BR-A-657	Angiotensin Receptor Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1 .

HY-P990951

Vixticibart REGN-5381	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .

HY-P0108

Angiotensin II 5-valine Valine angiotensin II; 5-L-Valine angiotensin II	Angiotensin Receptor	Endocrinology Cancer
Angiotensin II 5-valine is an agonist of *angiotensin receptor*.

HY-P2217

Aclerastide DSC-127; NorLeu3-A(1-7)	Angiotensin Receptor	Inflammation/Immunology
Aclerastide (DSC-127) is an *angiotensin receptor* agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers .

HY-126293

Apelin agonist 1	Apelin Receptor (APJ)	Cardiovascular Disease
Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. Apelin agonist 1 is extracted from patent WO 2018097944 (210.0), Example 210.0 .

HY-101542

Milfasartan LR-B/081	Angiotensin Receptor	Cardiovascular Disease
Milfasartan (LR-B/081) is a selective angiotensin receptor AT1 antagonist with antihypertensive activity .

HY-165425

KR31173	Angiotensin Receptor	Cardiovascular Disease
KR31173 is an AT1 antagonist with an IC₅₀ of 3.27  nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice .

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library	893 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 893 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

893 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 893 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Angiotensin II 5-valine Valine angiotensin II; 5-L-Valine angiotensin II	Angiotensin Receptor	Endocrinology Cancer
Angiotensin II 5-valine is an agonist of *angiotensin receptor*.

Aclerastide DSC-127; NorLeu3-A(1-7)	Angiotensin Receptor	Inflammation/Immunology
Aclerastide (DSC-127) is an *angiotensin receptor* agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990951

Vixticibart REGN-5381	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705991

	APLNR Protein-VLP, Rhesus Macaque (HEK293, His) Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ	Rhesus Macaque	HEK293
	APJ-MSP1D1 Protein-VLP, Rhesus Macaque (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) mouse (1) Rat (2) Mouse (2) rat (1)
Application:	WB FC ICC/IF (1) ICC/IF (1) IP (1) WB (2) FC (1)
Isotype:	IgG (2) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P810472

	AGTR2 Antibody (YA9770) AGTR2, Angiotensin II Receptor Type 2, MRX88, AT2, Type-2 Angiotensin II Receptor, Angiotensin II Type-2 Receptor, AT2 Receptor, Angiotensin Receptor 2, ATGR2	WB FC ICC/IF	Human, mouse, rat
	AGTR2 Antibody (YA9770) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to AGTR2.

HY-P810406

	Angiotensin II Type 1 Receptor Antibody (YA9721) AG2S, Agtr 1, Agtr1, AGTR1_HUMAN, Agtr1a, AGTR1B, Ang II, Angiotensin II receptor type 1, Angiotensin II type-1 receptor, Angiotensin receptor 1	WB, ICC/IF, FC	Human, Mouse, Rat
	Angiotensin II Type 1 Receptor Antibody (YA9721) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Angiotensin II Type 1 Receptor.

HY-P83345

	AGTR2 Antibody (YA3090) AGTR2; Angiotensin ii receptor type 2; Angiotensin II type-2 receptor; AT2 receptor; AT2; At2r; MRX88; Angiotensin ii at2; Angiotensin receptor 2; Type-2 angiotensin II receptor; ATGR2	WB, IP	Human, Mouse, Rat
	AGTR2 Antibody (YA3090) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AGTR2.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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