2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Aclerastide

Aclerastide  (Synonyms: DSC-127; NorLeu3-A(1-7))

Cat. No.: HY-P2217 Purity: 99.85%
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Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Aclerastide Chemical Structure

Aclerastide Chemical Structure

CAS No. : 227803-63-6

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1 mg USD 85 In-stock
5 mg USD 210 In-stock
10 mg USD 340 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Aclerastide Related Antibodies

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Description

Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].

In Vivo

Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1].
Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[2]
Dosage: 100 μL
Administration: Topically administered, once a day, for 14 days
Result: Upregulated reactive oxygen species during inflammation.
Increased the levels of the detrimental active MMP-9 in diabetic wounds.
Clinical Trial
Molecular Weight

913.03

Formula

C42H64N12O11
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Asp-Arg-{Nle}-Tyr-Ile-His-Pro
Sequence Shortening

DR-{Nle}-YIHP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (109.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0953 mL 5.4763 mL 10.9525 mL
5 mM 0.2191 mL 1.0953 mL 2.1905 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0953 mL 5.4763 mL 10.9525 mL 27.3814 mL
5 mM 0.2191 mL 1.0953 mL 2.1905 mL 5.4763 mL
10 mM 0.1095 mL 0.5476 mL 1.0953 mL 2.7381 mL
15 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8254 mL
20 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3691 mL
25 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
30 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
40 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
50 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5476 mL
60 mM 0.0183 mL 0.0913 mL 0.1825 mL 0.4564 mL
80 mM 0.0137 mL 0.0685 mL 0.1369 mL 0.3423 mL
100 mM 0.0110 mL 0.0548 mL 0.1095 mL 0.2738 mL
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Aclerastide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aclerastide227803-63-6DSC-127 NorLeu3-A(1-7)DSC127DSC 127Angiotensin Receptorangiotensin receptorpeptide analogtissue regenerationdiabetic ulcersInhibitorinhibitorinhibit

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