AGTR2 Antibody (YA9770)
(Synonyms: AGTR2, Angiotensin II Receptor Type 2, MRX88, AT2, Type-2 Angiotensin II Receptor, Angiotensin II Type-2 Receptor, AT2 Receptor, Angiotensin Receptor 2, ATGR2)AGTR2 Antibody (YA9770) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to AGTR2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, ICC/IF
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Reactivity :
Human, mouse, rat
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:200-2000 | 1:100-1000 |
Product Details
AGTR2 Antibody (YA9770) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to AGTR2.
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Host Rabbit
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Species ReactivityHuman, mouse, rat
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
A synthesized peptide derived from human AGTR2
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AGTR2 is a Receptor for angiotensin II, a vasoconstricting peptide. Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation[1][2][3][4][5].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. -
Isoforms & Post-Translational Modification
AGTR2 has an amino acid length of 363, molecular weight is 41184 Da.
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Subunit
Interacts with MTUS1
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SwissProt ID
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Synonyms
AGTR2, Angiotensin II Receptor Type 2, MRX88, AT2, Type-2 Angiotensin II Receptor, Angiotensin II Type-2 Receptor, AT2 Receptor, Angiotensin Receptor 2, ATGR2
Documentation
References
[1]. Zhang H, et al. Structural basis for selectivity and diversity in angiotensin II receptors. Nature. 2017 Apr 20;544(7650):327-332. [Content Brief]
[2]. Asada H, et al. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nat Struct Mol Biol. 2018 Jul;25(7):570-576. [Content Brief]
[3]. Asada H, et al. The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure. 2020 Apr 7;28(4):418-425.e4. [Content Brief]
[4]. Tsuzuki S, et al. Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1994 May 16;200(3):1449-54. [Content Brief]
[5]. Nouet S, et al. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem. 2004 Jul 9;279(28):28989-97. [Content Brief]
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