1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Angiotensin II 5-valine

Angiotensin II 5-valine  (Synonyms: Valine angiotensin II; 5-L-Valine angiotensin II)

Cat. No.: HY-P0108 Purity: 99.66%
COA Handling Instructions

Angiotensin II 5-valine is an agonist of angiotensin receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II 5-valine Chemical Structure

Angiotensin II 5-valine Chemical Structure

CAS No. : 58-49-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
USD 89 In-stock
Solution
10 mM * 1 mL in Water USD 89 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 78 In-stock
50 mg USD 90 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Angiotensin II 5-valine is an agonist of angiotensin receptor.

IC50 & Target

Angiotensin receptor[1].

In Vivo

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1032.15

Formula

C49H69N13O12

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe

Sequence Shortening

DRVYVHPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (96.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9689 mL 4.8443 mL 9.6885 mL
5 mM 0.1938 mL 0.9689 mL 1.9377 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (32.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.66%

References
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9689 mL 4.8443 mL 9.6885 mL 24.2213 mL
5 mM 0.1938 mL 0.9689 mL 1.9377 mL 4.8443 mL
10 mM 0.0969 mL 0.4844 mL 0.9689 mL 2.4221 mL
15 mM 0.0646 mL 0.3230 mL 0.6459 mL 1.6148 mL
20 mM 0.0484 mL 0.2422 mL 0.4844 mL 1.2111 mL
25 mM 0.0388 mL 0.1938 mL 0.3875 mL 0.9689 mL
30 mM 0.0323 mL 0.1615 mL 0.3230 mL 0.8074 mL
40 mM 0.0242 mL 0.1211 mL 0.2422 mL 0.6055 mL
50 mM 0.0194 mL 0.0969 mL 0.1938 mL 0.4844 mL
60 mM 0.0161 mL 0.0807 mL 0.1615 mL 0.4037 mL
80 mM 0.0121 mL 0.0606 mL 0.1211 mL 0.3028 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Angiotensin II 5-valine
Cat. No.:
HY-P0108
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