2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Angiotensin II 5-valine

Angiotensin II 5-valine  (Synonyms: Valine angiotensin II; 5-L-Valine angiotensin II)

Cat. No.: HY-P0108 Purity: 99.77%
COA Handling Instructions

Angiotensin II 5-valine is an agonist of angiotensin receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II 5-valine Chemical Structure

Angiotensin II 5-valine Chemical Structure

CAS No. : 58-49-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 89 In-stock
Solution
10 mM * 1 mL in Water USD 89 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 78 In-stock
50 mg USD 90 In-stock
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Based on 1 publication(s) in Google Scholar

Angiotensin II 5-valine Related Antibodies

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Description

Angiotensin II 5-valine is an agonist of angiotensin receptor.

IC50 & Target

Angiotensin receptor[1].
In Vivo

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1032.15

Appearance

Solid

Formula

C49H69N13O12
CAS No.
Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe
Sequence Shortening

DRVYVHPF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (96.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9689 mL 4.8443 mL 9.6885 mL
5 mM 0.1938 mL 0.9689 mL 1.9377 mL
10 mM 0.0969 mL 0.4844 mL 0.9689 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (32.29 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.77%

COA (252 KB) LCMS (254 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Angiotensin II 5-valine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Angiotensin II 5-valine58-49-1Valine angiotensin II 5-L-Valine angiotensin IIAngiotensin ReceptorInhibitorinhibitorinhibit

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