1. GPCR/G Protein
  2. Angiotensin Receptor

Angiotensin II 5-valine (Synonyms: Valine angiotensin II; 5-L-Valine angiotensin II)

Cat. No.: HY-P0108 Purity: 95.90%
Handling Instructions

Angiotensin II 5-valine is an agonist of angiotensin receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II 5-valine Chemical Structure

Angiotensin II 5-valine Chemical Structure

CAS No. : 58-49-1

Size Price Stock Quantity
10 mM * 1 mL in Water USD 89 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 144 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Angiotensin II 5-valine is an agonist of angiotensin receptor.

IC50 & Target

Angiotensin receptor[1].

In Vivo

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

Solvent & Solubility
In Vitro: 

H2O : ≥ 257.5 mg/mL (249.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9689 mL 4.8443 mL 9.6885 mL
5 mM 0.1938 mL 0.9689 mL 1.9377 mL
10 mM 0.0969 mL 0.4844 mL 0.9689 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1032.15

Formula

C₄₉H₆₉N₁₃O₁₂

CAS No.

58-49-1

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Angiotensin II 5-valine
Cat. No.:
HY-P0108
Quantity:

Angiotensin II 5-valine

Cat. No.: HY-P0108