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Cucurbitaceae

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By Targets:	Akt (1) Apoptosis (4) Autophagy (3) Bacterial (1) Bcl-2 Family (2) Caspase (3) CDK (1) Drug Derivative (1) ERK (2) NF-κB (2) p38 MAPK (2) PANoptosis (1) PARP (2) Reference Standards (2)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (2)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0213

Peiminine 5+ Cited Publications Verticinone; Raddeanine	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-N12461

Cucurbitacin F	Bacterial Caspase Apoptosis	Infection
Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis .

HY-N10685

3,7,25-Trihydroxycucurbita-5,23-dien-19-al TCD	Drug Derivative	Others Cancer
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .

HY-N0417R

Cucurbitacin E (Standard) α-Elaterin (Standard); α-Elaterine (Standard)	Reference Standards CDK Autophagy PANoptosis	Cancer
Cucurbitacin E (Standard) is the analytical standard of Cucurbitacin E. This product is intended for research and analytical applications. Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

HY-N9968

Cucurbitacin C	Akt Apoptosis	Cancer
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-N12552

Cucurbitacin IIa 2-O-β-D-glucoside Hemslecin A 2-O-β-d-glucopyranoside	Others	Infection
Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .

HY-N12327

Ombuin-3-O-glucoside	Others	Others
Ombuin-3-O-glucoside is a flavonoid glycoside derived from Gynostemma pentaphyllum. Ombuin-3-O-glucoside has antioxidant activity .

HY-N0213R

Peiminine (Standard) Verticinone (Standard); Raddeanine (Standard)	Reference Standards Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-N9885

Xuedanencins D	Others	Cancer
Xuedanencins D is a cucurbitane-type triterpenoid natural product without significant cytotoxicity against human cervical cancer HeLa cells (IC₅₀ >100 μM). Xuedanencins D can be naturally extracted from the 95% ethanol extract of the tubers of Hemsleya penxianensis (a plant of the Hemsleya genus in the Cucurbitaceae family) .

Peiminine 5+ Cited Publications Verticinone; Raddeanine	Alkaloids Piperidine Alkaloids Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Cucurbitacin F	Triterpenes Structural Classification Hemsleya gigantha W. J. Chang Terpenoids Cucurbitaceae Plants Source Classification	Bacterial Caspase Apoptosis
Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis .

3,7,25-Trihydroxycucurbita-5,23-dien-19-al TCD	Triterpenes Structural Classification Anthocyans Flavonoids Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Drug Derivative
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .

Cucurbitacin E (Standard) α-Elaterin (Standard); α-Elaterine (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Source Classification	Reference Standards CDK Autophagy PANoptosis
Cucurbitacin E (Standard) is the analytical standard of Cucurbitacin E. This product is intended for research and analytical applications. Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

Cucurbitacin C	Triterpenes Terpenoids Cucurbitaceae Plants Cucumis sativus L. Source Classification	Akt Apoptosis
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

Cucurbitacin IIa 2-O-β-D-glucoside Hemslecin A 2-O-β-d-glucopyranoside	Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Saccharides Monosaccharides Source Classification	Others
Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .

Ombuin-3-O-glucoside	Flavonoids Flavones Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Saccharides Monosaccharides Source Classification	Others
Ombuin-3-O-glucoside is a flavonoid glycoside derived from Gynostemma pentaphyllum. Ombuin-3-O-glucoside has antioxidant activity .

Peiminine (Standard) Verticinone (Standard); Raddeanine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Plants Source Classification	Reference Standards Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Xuedanencins D	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Hemsleya pengxianensis W. J. Chang Source Classification	Others
Xuedanencins D is a cucurbitane-type triterpenoid natural product without significant cytotoxicity against human cervical cancer HeLa cells (IC₅₀ >100 μM). Xuedanencins D can be naturally extracted from the 95% ethanol extract of the tubers of Hemsleya penxianensis (a plant of the Hemsleya genus in the Cucurbitaceae family) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Cucurbitaceae

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