Cucurbitacin F
Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 5939-57-1
- Formula: C30H46O7
- Molecular Weight:518.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9 | EC50 |
0.06 μg/mL
Compound: 1
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Tested for anti-HIV activity against acutely infected H9 cells, activity expressed as EC50.
Tested for anti-HIV activity against acutely infected H9 cells, activity expressed as EC50.
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10.1016/S0960-894X(01)80354-1 |
| H9 | IC50 |
0.16 μg/mL
Compound: 1
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Concentration required for anti-HIV activity against acutely infected H9 cells
Concentration required for anti-HIV activity against acutely infected H9 cells
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10.1016/S0960-894X(01)80354-1 |
| KB | ED50 |
0.074 μg/mL
Compound: 1
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 6549470] |
| P388 | ED50 |
0.04 μg/mL
Compound: 1
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 6549470] |
Cucurbitacin F exhibits significant cytotoxicity against several unspecified tumor cell lines with an ED50 of <0.1 μg/mL[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BDF-1 Mice[4]
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Dosage:2.5 mg/kg/day
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Administration:daily
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Result:Observed acute toxicity in BDF-1 mice.
Chemical Information
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CAS No. 5939-57-1
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Molecular Weight 518.68
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Formula C30H46O7
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SMILES
C[C@]12[C@@]([C@@]([C@@H](C1)O)([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H]([C@H](C4(C)C)O)O)C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yin D, et al. Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent. Int J Mol Sci. 2025;26(16):8003. Published 2025 Aug 19. [Content Brief]
[2]. Lohberger B, et al. 25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells. J Ethnopharmacol. 2015;164:265-272. [Content Brief]
[3]. Sörensen PM, et al. The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol. 2012;7(9):1502-1508. [Content Brief]
[5]. Yang P, et al. Separation of Cucurbitacins by Overpressure Layer Chromatography from Hemsleya gigantha1. Planta Med. 1988 Aug;54(4):349-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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