2. Anti-infection Apoptosis
  3. Bacterial Caspase Apoptosis
  4. Cucurbitacin F

Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis.

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Cucurbitacin F

Cucurbitacin F Chemical Structure

CAS No. : 5939-57-1

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Cucurbitacin F Related Antibodies

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Description

Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis[1][2][3][4][5].

Cellular Effect
Cell Line Type Value Description References
H9 EC50
0.06 μg/mL
Compound: 1
Tested for anti-HIV activity against acutely infected H9 cells, activity expressed as EC50.
Tested for anti-HIV activity against acutely infected H9 cells, activity expressed as EC50.
10.1016/S0960-894X(01)80354-1
H9 IC50
0.16 μg/mL
Compound: 1
Concentration required for anti-HIV activity against acutely infected H9 cells
Concentration required for anti-HIV activity against acutely infected H9 cells
10.1016/S0960-894X(01)80354-1
KB ED50
0.074 μg/mL
Compound: 1
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
[PMID: 6549470]
P388 ED50
0.04 μg/mL
Compound: 1
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 6549470]
In Vitro

Cucurbitacin F exhibits significant cytotoxicity against several unspecified tumor cell lines with an ED50 of <0.1 μg/mL[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cucurbitacin F Related Antibodies
In Vivo

Cucurbitacin F (2.5 mg/kg/day; daily) exhibits acute toxicity in BDF-1 mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BDF-1 Mice[4]
Dosage: 2.5 mg/kg/day
Administration: daily
Result: Observed acute toxicity in BDF-1 mice.
Molecular Weight

518.68

Formula

C30H46O7
CAS No.
SMILES

C[C@]12[C@@]([C@@]([C@@H](C1)O)([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H]([C@H](C4(C)C)O)O)C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cucurbitacin F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cucurbitacin F5939-57-1BacterialCaspaseApoptosisG2/M cell cycle arrestcaspase-3-dependent apoptosistumor cell linesPhysocarpus capitatusCucurbitaceae plantsSorbaria sorbifoliaBDF-1 miceactinQuisqualis indicaInhibitorinhibitorinhibit

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