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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
D2 domain
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "D2 domain" in MCE Product Catalog:
8
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Research Areas:
8
8 Publications Verification
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
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3
3 Cited Publications
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NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .
Cat. No.: HY-175200
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DEL-S1 is a SLIT2 binder. DEL-S1 significantly inhibits the formation of the SLIT2/ROBO1 complex by inducing conformational rearrangement, and further suppresses its function, with an IC50 of 68.8 μM. DEL-S1 can be used in studies of neurodevelopment, immunomodulation, and cancers such as glioblastoma .
Cat. No.: HY-W013049S2
CAS No.: 71607-34-6
Synonyms: Behenic acid-d2
Cat. No.: HY-124253
CAS No.: 1147823-21-9
SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting p97 AAA+ ATPase, with an IC50 of 3.5 μM and a Ka of 9.1 μM. SMDC818909 binds to the D2 ATPase domain of p97, preferentially associates with the ADP-bound conformation of p97, allosterically blocks the ATP hydrolysis cycle of p97, and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms .
Cat. No.: HY-184291
CAS No.: 3114314-82-5
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VCP/p97 IN-4 is a p97/VCP inhibitor (Kd=14.99 μM) targeting the allosteric site of the D1-D2 domain. VCP/p97 IN-4 inhibits the ATPase activity of VCP/p97 in an ATP concentration-independent manner. VCP/p97 IN-4 induces apoptosis, autophagy, mitochondrial stress and mitochondrial membrane depolarization. VCP/p97 IN-4 inhibits the growth of patient-derived colorectal cancer organoids and exhibits in vivo efficacy in a colorectal cancer xenograft mouse model. VCP/p97 IN-4 can be used for the research of colorectal cancer .
Cat. No.: HY-185816
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TQB2102 is a bispecific epitope antibody-drug conjugate targeting HER2, composed of the antibody Rolditamig (HY-P992130) and the toxin molecule Deruxtecan-d2 (HY-13631ES3). TQB2102 binds to the ECD2 and ECD4 domains of HER2, promotes its own internalization by HER2-expressing cells, and delivers deuterated DXd payload to inhibit topoisomerase I. TQB2102 induces antibody-dependent cellular cytotoxicity, DNA damage, bystander killing activity, and inhibits cancer cell proliferation. TQB2102 can be used in research related to various cancers including metastatic breast cancer, colorectal cancer, and gastric/gastroesophageal junction adenocarcinoma .
Cat. No.: HY-103693R
CAS No.: 2809469-05-2
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NAZ2329 (Standard) is the analytical standard of NAZ2329 (HY-103693). This product is intended for research and analytical applications. NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .
Cat. No.: HY-187218
TBC1D2-IN-2 is an orally potent TBC1D2 inhibitor that binds to the TBC1D2 PH domain with a KD of 0.4 μM. TBC1D2-IN-2 induces autophagic cell death by reducing TBC1D2 protein levels, promoting RAB7A aggregation and enhancing autophagy. TBC1D2-IN-2 can be used in the research of hepatocellular carcinoma .
Cat. No.: HY-P88862A
Synonyms: PIH1 domain containing 2
Cat. No.: HY-P76955
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GLT8D2; FLJ31494; Glycosyltransferase 8 domain Containing 2; GALA4A; Glycosyltransferase 8 domain-Containing Protein 2
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Cat. No.: HY-149590
CAS No.: 200348-48-7
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IPA is a specific Sec18/NSF inhibitor. IPA binds to phosphatidic acid competitively, induces conformational rigidification of Sec18/NSF, disrupts its essential flexibility, and blocks SNARE priming and vacuolar membrane fusion. IPA can be used to investigate the activity of Sec18 and SNARE priming kinetics .
Cat. No.: HY-P701603
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZFAND5; Zinc Finger AN1‑Type Containing 5; ZA20D2; ZNF216; Zinc Finger Protein 216; ZFAND5A; Zinc Finger A20 domain‑Containing Protein 2; Zinc Finger, A20 domain Containing 2; Zinc Finger, AN1‑Type domain 5; AN1‑Type Zinc Finger Protein 5
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Cat. No.: HY-P76866
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCUN1D2; DCNL2; Prev. C13orf17; DCN1, Defective In Cullin Neddylation 1, domain Containing 2; Defective In Cullin Neddylation Protein 1-Like Protein 2; Defective In Cullin Neddylation Protein 1-Like Protein; DCUN1 domain-Containing Protein 2; Chromosome 1
Cat. No.: HY-P701604
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZFAND5; Zinc Finger AN1‑Type Containing 5; ZA20D2; ZNF216; Zinc Finger Protein 216; ZFAND5A; Zinc Finger A20 domain‑Containing Protein 2; Zinc Finger, A20 domain Containing 2; Zinc Finger, AN1‑Type domain 5; AN1‑Type Zinc Finger Protein 5
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Cat. No.: HY-P76954
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: COLGALT2; Glycosyltransferase 25 Family Member 2; Prev. C1orf17; Procollagen Galactosyltransferase 2; Prev. GLT25D2; ColGalT 2; KIAA0584; Chromosome 1 Open Reading Frame 17; Glycosyltransferase 25 domain Containing 2; Procollagen Galactosyltransferase; Co
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Cat. No.: HY-P84972
Synonyms: CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E; C-X-C chemokine receptor type 4 antibody; CD184 antibody; CD184 antigen antibody; Chemokine; C X C motif; receptor 4 antibody; Chemokine CXC Motif Receptor 4 antibody; CXC-R4 antibody; CXCR-4 antibody; CXCR4 antibody; CXCR4_HUMAN antibody; D2S201E antibody; FB22 antibody; Fusin antibody; HM89 antibody; HSY3RR antibody; LAP 3 antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; Leukocyte derived seven transmembrane domain receptor antibody; Leukocyte-derived seven transmembrane domain receptor antibody; Lipopolysaccharide associated protein 3 antibody; Neuropeptide Y receptor Y3 antibody; NPY3R antibody; NPYR antibody; NPYRL antibody; NPYY3 antibody; NPYY3R antibody; Probable G protein coupled receptor lcr1 homolog antibody; SDF 1 receptor antibody; SDF-1 receptor antibody; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody; Stromal cell derived factor 1 receptor antibody; Stromal cell-derived factor 1 receptor antibody; WHIM antibody; WHIMS antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
