2. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
  3. iGluR
    NO Synthase
  4. Tat-NR2B9c TFA

Tat-NR2B9c TFA  (Synonyms: Tat-NR2Bct TFA; NA-1 TFA)

Cat. No.: HY-P0117A Purity: 99.67%
COA Handling Instructions

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tat-NR2B9c TFA Chemical Structure

Tat-NR2B9c TFA Chemical Structure

CAS No. : 1834571-04-8

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1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Tat-NR2B9c TFA:

Top Publications Citing Use of Products

    Tat-NR2B9c TFA purchased from MCE. Usage Cited in: J Cereb Blood Flow Metab. 2019 Aug;39(8):1588-1601.  [Abstract]

    Tat-NR2B9c affects PSD95-NR2B-nNOS complex and PSD95-neurexin-neuroligin complex formation after ICH. Western blots of IP with PSD95 antibody show the interactions between nNOS, NR2B, neurexin-1 or neuroligin-1, and PSD95.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1].

    IC50 & Target

    NMDA Receptor

     

    nNOS

     

    In Vitro

    Tat-NR2B9c is a PSD-95 inhibitor, with an EC50 of 6.7 nM for PSD-95d2, representing a >100-fold higher affinity for this domain than for PSD-95d1 (EC50, 0.67 μM). Tat-NR2B9c inhibits NMDAR2A, NMDAR2B, and NMDAR2C binding to PSD-95, with IC50s of 0.5 μM, ∼8 μM, and 0.75 μM, respectively.
    Tat-NR2B9c also blocks the interaction between PSD-95 and nNOS with an IC50 of ∼0.2 μM[1].
    Tat-NR2B9c reduces association of PSD-95 with GluN2B by ∼50% in the YAC128 striatum, decreases NMDA-induced p38 activation in YAC128 striatal tissue, but shows no effect on the NMDA-induced JNK activation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    In Vivo

    Tat-NR2B9c (10 nmol/g, i.v.) reduces infarction volume of male C57BL/6 mice, but has no effect at 3 nmol/g[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    2632.90

    Appearance

    Solid

    Formula

    C105H188N42O30.C2HF3O2
    CAS No.
    Sequence Shortening

    YGRKKRRQRRRKLSSIESDV
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (18.99 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.3798 mL 1.8990 mL 3.7981 mL
    5 mM 0.0760 mL 0.3798 mL 0.7596 mL
    10 mM 0.0380 mL 0.1899 mL 0.3798 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (37.98 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.67%

    COA (241 KB) RP-HPLC (115 KB) MS (187 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Tat-NR2B9c1834571-04-8Tat-NR2BctNA-1NA1NA 1iGluRNO SynthaseIonotropic glutamate receptorsNitric oxide synthasesNOSInhibitorinhibitorinhibit

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