1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
  2. iGluR
    NO Synthase
  3. Tat-NR2B9c TFA

Tat-NR2B9c TFA (Synonyms: NA-1 (TFA))

Cat. No.: HY-P0117A Purity: 98.99%
Handling Instructions

Tat-NR2B9c TFA (NA-1 TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1. Tat-NR2B9c also reduces NMDA-induced p38 activation, inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.

For research use only. We do not sell to patients.

Tat-NR2B9c TFA Chemical Structure

Tat-NR2B9c TFA Chemical Structure

CAS No. : 1834571-04-8

Size Price Stock Quantity
10 mM * 1 mL in Water USD 105 In-stock
Estimated Time of Arrival: December 31
1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Tat-NR2B9c TFA:

Top Publications Citing Use of Products

    Tat-NR2B9c TFA purchased from MCE. Usage Cited in: J Cereb Blood Flow Metab. 2018 Mar 7:271678X18762637.

    Tat-NR2B9c affects PSD95-NR2B-nNOS complex and PSD95-neurexin-neuroligin complex formation after ICH. Western blots of IP with PSD95 antibody show the interactions between nNOS, NR2B, neurexin-1 or neuroligin-1, and PSD95.
    • Biological Activity

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    Description

    Tat-NR2B9c TFA (NA-1 TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1][2].

    IC50 & Target

    EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]
    NO synthase[1]

    Molecular Weight

    114.02

    Formula

    C₂HF₃O₂

    CAS No.

    1834571-04-8

    Sequence

    Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val

    Sequence Shortening

    YGRKKRRQRRRKLSSIESDV

    SMILES

    OC(C(F)(F)F)=O.[YGRKKRRQRRRKLSSIESDV]

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    -20°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (438.52 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.7704 mL 43.8520 mL 87.7039 mL
    5 mM 1.7541 mL 8.7704 mL 17.5408 mL
    10 mM 0.8770 mL 4.3852 mL 8.7704 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Product Name:
    Tat-NR2B9c TFA
    Cat. No.:
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