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DHPS

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By Targets:	Antibiotic (3) Apoptosis (1) Bacterial (4) Calcium Channel (3) DNA/RNA Synthesis (4) Isotope-Labeled Compounds (2) Necroptosis (1) RIP kinase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (4) Inflammation/Immunology (3)

14

Inhibitors & Agonists

1

Recombinant Proteins

3

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115712

DHPS-IN-1

DNA/RNA Synthesis Cancer

DHPS-IN-1, with the best DHPS inhibitory potency (IC₅₀ = 0.014 μM), exhibits excellent inhibition against melanoma cells.
HY-108314A

GC7 Sulfate

3 Publications Verification

DNA/RNA Synthesis Cancer

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

DHPS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DHPS Human Pre-designed siRNA Set A contains three designed siRNAs for DHPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DHPS Human Pre-designed siRNA Set A DHPS Human Pre-designed siRNA Set A

DHP-B	Apoptosis	Cancer
DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis .

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

Sulfapyridine	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC₅₀ of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-B0612DS1

Lercanidipine-d3 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

Sodium 4-aminosalicylate dihydrate 4-Aminosalicylic acid sodium salt dihydrate	Bacterial Antibiotic	Infection
Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase (DHFR) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity .

Lercanidipine-13C,d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

RIP1 kinase inhibitor 8	Necroptosis RIP kinase	Inflammation/Immunology
RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC₅₀ of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species .

Dihydropteroate synthase-IN-1	Bacterial	Infection
Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .

Sulfapyridine (Standard)	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC₅₀ of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

Cat. No.	Compare	Product Name	Species	Source

	Deoxyhypusine synthase/DHS Protein, Human (His) rHuDeoxyhypusine synthase/DHS, His; Deoxyhypusine Synthase; DHS; DHPS; DS	Human	E. coli
	The deoxyhorseuridine synthase (DHS) protein plays a crucial role in the NAD-dependent oxidative cleavage of spermidine, followed by the transfer of the butylamine moiety of spermidine to the ε-amino group of the eIF-5A precursor protein. On the key lysine. Deoxyhypusine synthase/DHS Protein, Human (His) is the recombinant human-derived Deoxyhypusine synthase/DHS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Deoxyhypusine synthase/DHS Protein, Human (His) is 369 a.a., with molecular weight of ~44.52 kDa.

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