1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. GC7 Sulfate

GC7 Sulfate 

Cat. No.: HY-108314A Purity: >98.0%
Handling Instructions

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

For research use only. We do not sell to patients.

GC7 Sulfate Chemical Structure

GC7 Sulfate Chemical Structure

CAS No. : 150417-90-6

Size Price Stock Quantity
10 mM * 1 mL in Water USD 285 In-stock
Estimated Time of Arrival: December 31
1 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

IC50 & Target

DHPS[1]

In Vitro

The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein[1]. Between 0 and 20 μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 Sulfate treatment, compare to untreated control. The activity of [3H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 Sulfate or higher concentration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

270.35

Formula

C₈H₂₂N₄O₄S

CAS No.

150417-90-6

SMILES

NC(NCCCCCCCN)=N.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 3 mg/mL (11.10 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6989 mL 18.4945 mL 36.9891 mL
5 mM 0.7398 mL 3.6989 mL 7.3978 mL
10 mM 0.3699 mL 1.8495 mL 3.6989 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Cell viability is analyzed with the MTS assay kit in accordance with the manufacturer’s protocols. Briefly, after treatment with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) in 96-well plates, cells are directly incubated with the MTS dye reagent for 1 h at 37°C in a 5 % CO2 atmosphere. The absorbance is read at 490 nm using a reader[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

GC7GC 7GC-7DNA/RNA SynthesisInhibitorinhibitorinhibit

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GC7 Sulfate
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