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GC-7

9 Cited Publications
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Based on 9 publication(s) in Google Scholar

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

It is advisable to consider the stable salt form (GC7 Sulfate) that retains the same biological activity.

For research use only. We do not sell to patients.

  • CAS No.: 150333-69-0
  • Formula: C8H20N4
  • Molecular Weight:172.27
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • GC-7 Chemical Structure
    GC-7 Chemical Structure
  • Experimental Validation Results for GC-7
  • Experimental Validation Results for GC-7
  • Experimental Validation Results for GC-7
  • Experimental Validation Results for GC-7
  • Experimental Validation Results for GC-7
CAS No.: 150333-69-0
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • GC-7 Chemical Structure
    GC-7 Chemical Structure
    1/16
  • 1/16

    GC-7 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):2095-2113. [Abstract]

    Customer Validation
     PC3 and DU145 cells were pretreated with GC7 (2 μmol/L) for 6 hours, then cultured for another 24 hours with the specified reagent, and cell viability was then assessed.

  • 1/16

    GC-7 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):2095-2113. [Abstract]

    Customer Validation
     Western blot analysis of Hyp-EIF5A, EIF5A, NRF2, and HMOX1 in PC3 cells. Endogenous polyamines in PC3 cells were depleted by incubation with 1 mmol/L DFMO for 2 days. Polyamine-depleted cells were pretreated with GC7 (2 μmol/L) for 6 hours, followed by treatment with Spd and erastin for 8 hours.

  • 1/16

    GC-7 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):2095-2113. [Abstract]

    Customer Validation
     GC 7 (2 mg/kg, intraperitoneal injection). The volume of the PC3 xenograft tumor was monitored every other day, and the tumor weight was divided into 4 groups.

  • 1/16

    GC-7 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Mar 19;15(1):2461. [Abstract]

    Customer Validation
     Cell viability in A549 or HT1080 cells treated with RSL3 following pre-treatment with 1 μM GC7 for 16 h and polyamines.

  • 1/16

    GC-7 purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2021 Nov.

    Customer Validation
     Experimental results show that GC7 inhibits hypoxanthine modification of eIF5A in a concentration-dependent manner.

  • GC-7