RIP1 kinase inhibitor 8
RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species.
For research use only. We do not sell to patients.
- CAS No.: 2226735-54-0
- Formula: C18H19F2N5O2
- Molecular Weight:375.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 20 nM (RIP1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
3.2 nM
Compound: 77
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Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminescent cell viability assay
Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminescent cell viability assay
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[PMID: 31013427] |
Chemical Information
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CAS No. 2226735-54-0
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Molecular Weight 375.37
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Formula C18H19F2N5O2
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SMILES
O=C(C1CCN(C2=NN=C(O2)C)CC1)N3[C@H](C4=CC(F)=CC(F)=C4)CC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RIP1 kinase inhibitor 8 Related Classifications
HY-155804 Related Classifications
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