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Cat. No.: HY-147721

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Dihydropteroate synthase-IN-1

Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material.

For research use only. We do not sell to patients.

CAS No.: 2418026-70-5
Formula: C₁₉H₂₃N₅O₄S₂
Molecular Weight:449.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Dihydropteroate synthase-IN-1 Chemical Structure

CAS No.: 2418026-70-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

DHPS^[1]

In Vitro

Dihydropteroate synthase-IN-1 (compound 5g) shows antimicrobial activities with MIC of 24.3, 26.3, 22.8, 20.6, 19.6, 23.2 µg/ml for S. pneumoniae, B. Subtilis, S. epidermidis, E. coli, P. vulgaris, K. pneumonia, respectively^[1].
Dihydropteroate synthase-IN-1 shows antifungal activity with MIC of 21.6, 20.3, 20.4 µg/ml for A. fumigates, S. racemosum, G. candidum, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2418026-70-5
Molecular Weight 449.55
Formula C₁₉H₂₃N₅O₄S₂
SMILES

CCN/C(SCC)=C(C(NC1=CC=C(C=C1)S(=O)(NC2=C(C(C)=NO2)C)=O)=O)/C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nasr T, et al. New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors. Bioorg Med Chem. 2020 May 1;28(9):115444. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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