1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. AV-153

AV-153 

Cat. No.: HY-135218
Handling Instructions

AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity.

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AV-153 Chemical Structure

AV-153 Chemical Structure

CAS No. : 27296-05-5

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Description

AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity[1][2][3].

In Vitro

AV-153 causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively[1].
AV-153 (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13-67%[1].

Molecular Weight

319.29

Formula

C₁₄H₁₈NNaO₆

CAS No.

27296-05-5

SMILES

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C(O[Na])=O)OCC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AV-153AV153AV 153DNA/RNA Synthesis1,4-dihydropyridine1,4-DHPDNAdamagerepairpoly(ADP)ribosylation antimutagenicstrandbreakthyminecytosineanti-cancerInhibitorinhibitorinhibit

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