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Factor+Xa+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Biochemical Assay Reagents (2) Cytochrome P450 (1) Endogenous Metabolite (3) Factor Xa (30) Isotope-Labeled Compounds (3) Kallikrein (2) Reference Standards (1) Ser/Thr Protease (2) Thrombin (10)
By Research Areas:	Cancer (2) Cardiovascular Disease (29) Infection (1) Inflammation/Immunology (1) Metabolic Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0597

Fondaparinux sodium 4 Publications Verification Fondaparin sodium; SR-90107A	Factor Xa	Cardiovascular Disease Cancer
Fondaparinux sodium is an antithrombin-dependent *factor Xa* inhibitor.

HY-119124

Edoxaban M4 D21-2393	Factor Xa	Cardiovascular Disease Inflammation/Immunology
Edoxaban M4 (D21-2393) is an orally active and selective *Factor Xa* inhibitor with a human Factor Xa IC₅₀ of 1.8 nM. Edoxaban M4 exhibits anticoagulant activity via Factor Xa inhibition. Edoxaban M4 can be used for the research of non-valvular atrial fibrillation, venous thromboembolisms, pulmonary embolism .

HY-18660

Ciraparantag PER977	Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag (PER977) is a thrombin and *factor Xa* inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-10724

Fidexaban ZK-807834; CI-1031	Factor Xa	Cardiovascular Disease
Fidexaban is a *Factor Xa* inhibitor and can be used in research of cardiovascular disease .

HY-W854549

Heparin pentasaccharide Fondaparinux free acid	Factor Xa	Cardiovascular Disease
Heparin pentasaccharide (Fondaparinux) is a chemically synthesized selective *factor Xa* inhibitor with anticoagulant activity. Heparin pentasaccharide can be utilized in researches related to venous thromboembolic events .

HY-166257

Lyso-sulfatide (bovine) Psychosine 3′-O-sulfate; Psychosine 3′-sulfate	Biochemical Assay Reagents Factor Xa	Metabolic Disease
Lyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent *factor Xa* inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .

HY-B0597R

Fondaparinux sodium (Standard) Fondaparin sodium (Standard); SR-90107A (Standard)	Reference Standards Factor Xa	Cardiovascular Disease Cancer
Fondaparinux (sodium) (Standard) is the analytical standard of Fondaparinux (sodium). This product is intended for research and analytical applications. Fondaparinux sodium is an antithrombin-dependent *factor Xa* inhibitor.

HY-12605

SAR107375	Thrombin	Metabolic Disease
SAR107375 is a potent and orally active dual thrombin and *factor Xa* inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-129973

4-Chlorophenylurea NSC-12971; 4-Chlorophenylurea	Factor Xa	Others
4-Chlorophenylurea is metabolite of diflubenzuron (HY-B1973). 4-Chlorophenylurea can be used to form *factor Xa* inhibitors .

HY-153817

FXIa-IN-13	Factor Xa	Cardiovascular Disease
FXIa-IN-13 (example 1) is an *Factor Xa* inhibitor with antithrombotic activity. FXIa-IN-13 inhibits arteriovenous thrombosis in vivo and in vitro .

HY-10782

KFA-1982	Factor Xa	Cardiovascular Disease
KFA-1982 is a potent, selective and orally active *factor Xa* inhibitor. KFA-1982 can be used for the research of cardiovascular disease, such as thrombosis .

HY-10769

ZK-813039	Factor Xa	Cardiovascular Disease
ZK-813039 is a potent and orally active *factor Xa* inhibitor. ZK-813039 can prolong prothrombin time. ZK-813039 can be used for the research of cardiovascular disease .

HY-W145053

ChloraMine-T hydrate Sodium chloro(4-methylbenzenesulfonyl)azanide hydrate	Factor Xa Bacterial	Infection
ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) is a common reagent in various synthetic processes. It has been used as a reagent in aminohydroxylation and allylic amination reactions, a nitrogen source in aziridination reactions of alkenes and alkenes, and deprotection of sulfur groups in sulfur-containing compounds. It has been used as a reagent in the synthesis of factor Xa inhibitors. ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) (0.2% w/v) is also an antimicrobial agent that kills Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae.

HY-19442

Idrabiotaparinux	Thrombin	Cardiovascular Disease
Idrabiotaparinux, a derivative of Idraparinux (HY-19691), is a novel synthetic anticoagulant that links Idraparinux, a specific, indirect factor Xa inhibitor, to biotin .

HY-10777

EMD 495235	Factor Xa	Cardiovascular Disease
EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i of 6.8 nM. EMD 495235 shows anticoagulant activities .

HY-10756

BMS-740808	Factor Xa	Cardiovascular Disease
BMS-740808 is a potent, selective and orally active *factor Xa* inhibitor with a K_i of 30 pM. BMS-740808 shows >1000-fold for factor Xa than other proteases .

HY-18660B

Ciraparantag acetate PER977 acetate	Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag (PER977) acetate is a thrombin and factor Xa inhibitor. Ciraparantag acetate is a broad-spectrum reversal agent for anticoagulants, including low molecular weight heparins, unfractionated heparins, and some direct oral anticoagulants, but not VKAs .

HY-125505

BI-11634	Factor Xa	Cardiovascular Disease
BI-11634 is a *factor Xa* inhibitor. BI-11634 is metabolized by CYP3A4 to form one major metabolite and this reaction is inhibited by Quinidine (HY-B1751H) with a K_i of 7 µM .

HY-12605S

SAR107375-d11 Tartrate	Isotope-Labeled Compounds Thrombin	Metabolic Disease
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and *factor Xa* inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-10778

BMS-269223	Factor Xa	Cardiovascular Disease
BMS-269223 is a potent, selective and orally active *factor Xa* inhibitor (K_i = 6.5 nM, EC2xPT = 32 μM). BMS-269223 can prolong prothrombin time and inhibit thrombosis formation. BMS-269223 can be used for the research of cardiovascular disease .

HY-18660A

Ciraparantag TFA PER977 TFA	Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag (PER977) TFA is a thrombin and *factor Xa* inhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-11091

Razaxaban hydrochloride BMS 561389 hydrochloride; DPC 906 hydrochloride	Factor Xa Thrombin	Cardiovascular Disease
Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active *factor Xa* inhibitor with a K_i of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a K_i of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity .

HY-10779

BMS-344577	Factor Xa Cytochrome P450	Cardiovascular Disease
BMS-344577 (Compound 22) is a potent and orally active *factor Xa* inhibitor (IC₅₀ = 4 nM, EC2xPT = 7 μM). BMS-344577 shows potent CYP3A4 inhibition activity (IC₅₀ = 0.3 μM). BMS-344577 can be used for the research of cardiovascular disease .

HY-10281

YM-60828 methanesulfonate	Factor Xa	Cardiovascular Disease
YM-60828 methanesulfonate is an orally active, selective and competitive *factor Xa* inhibitor with a K_i of 1.3 nM and an IC50 of 2.3 nM. YM-60828 methanesulfonate inhibits thrombus formation and platelet aggregation. YM-60828 methanesulfonate can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .

HY-10264D

(1R,2R,4R)-Edoxaban (1R,2R,4R)-DU-176	Factor Xa	Cardiovascular Disease
(1R,2R,4R)-Edoxaban is an oxalamide derivative. (1R,2R,4R)-Edoxaban is an activated coagulation factor X (Factor Xa) inhibitor. (1R,2R,4R)-Edoxaban can be used in the study of thrombosis .

HY-18660S

Ciraparantag-d8 (tetra(hydrochloride) diacetate) PER977-d8 tetrahydrochloride diacetate	Isotope-Labeled Compounds Factor Xa Thrombin	Cardiovascular Disease
Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and *factor Xa* inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-11090A

DPC423	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 is a selective and orally active *factor Xa* inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis .

HY-11090

DPC423 free base	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 free base is a selective and orally active *factor Xa* inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis .

HY-17682

RPR-208707	Factor Xa	Cardiovascular Disease
RPR-208707 is a selective *factor Xa* inhibitor with a K_i of 18 nM. RPR-208707 can be used for research of thrombosis-related diseases .

HY-19517

R1663	Endogenous Metabolite	Cardiovascular Disease
R1663 is a factor Xa inhibitor with anticoagulant activity. R1663 does not affect bleeding time. The pharmacodynamic effects (such as inhibition of thrombin generation) and plasma concentrations of R1663 are dose-dependent. R1663 prolongs clotting time in a concentration-dependent manner and inhibits the peak height of thrombin generation and endogenous thrombin potential .

HY-10279

YM-60828 hydrochloride	Factor Xa	Cardiovascular Disease
YM-60828 hydrochloride is an orally active, selective and competitive *factor Xa* inhibitor with a K_i of 1.3 nM and an IC50 of 2.3 nM. YM-60828 hydrochloride inhibits thrombus formation and platelet aggregation. YM-60828 hydrochloride can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .

HY-182420

DJT06001	Factor Xa	Cardiovascular Disease
DJT06001 is an orally active, highly selective *Factor Xa* inhibitor. DJT06001 shows inhibition with K_i of 0.99 nM, IC₅₀ of 2.53 nM in prothrombinase complex and 3.33 nM in human plasma. DJT06001 dose-dependently prolongs PT and APTT, inhibits thrombus formation in vivo. DJT06001 can be used for the research of thromboembolic diseases .

HY-165180

Lyso-sulfatide (bovine) sodium Psychosine 3′-O-sulfate sodium; Psychosine 3′-sulfate sodium	Biochemical Assay Reagents Factor Xa	Metabolic Disease
Lyso-sulfatide (bovine) sodium is a phospholipid component derived from sphingolipid catabolism and a potent *factor Xa* inhibitor and anticoagulant. Lyso-sulfatide (bovine) sodium binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) sodium serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .

HY-10780

JTV-803 mesylate	Endogenous Metabolite	Cardiovascular Disease
JTV-803 mesylate is a human factor Xa inhibitor with oral anticoagulant activity. JTV-803 exhibits competitive inhibition of human factor Xa, with a K_i value of 0.019μM and IC₅₀Value is 0.081μM. JTV-803 is 100 times more selective at inhibiting human factor Xa than its comparator. JTV-803 is an effective oral anticoagulant for the prevention of thrombosis .

HY-10280S

YM-60828-d3	Isotope-Labeled Compounds Factor Xa	Others
YM-60828-d₃ is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive *factor Xa* inhibitor with a K_i of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .

HY-135541

Darexaban maleate YM150 maleate	Endogenous Metabolite	Cardiovascular Disease
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .

Heparin pentasaccharide Fondaparinux free acid	Biochemical Assay Reagents
Heparin pentasaccharide (Fondaparinux) is a chemically synthesized selective *factor Xa* inhibitor with anticoagulant activity. Heparin pentasaccharide can be utilized in researches related to venous thromboembolic events .

Cat. No.	Product Name	Chemical Structure

HY-12605S

SAR107375-d11 Tartrate
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and *factor Xa* inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-18660S

Ciraparantag-d8 (tetra(hydrochloride) diacetate)
Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and *factor Xa* inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

Ciraparantag-d8 (tetra(hydrochloride) diacetate)

Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-10280S

YM-60828-d3
YM-60828-d₃ is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive *factor Xa* inhibitor with a K_i of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders .

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