1. Metabolic Enzyme/Protease
  2. Factor Xa
  3. Fondaparinux sodium

Fondaparinux sodium  (Synonyms: Fondaparin sodium; SR-90107A)

Cat. No.: HY-B0597 Purity: ≥98.0%
COA Handling Instructions

Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

For research use only. We do not sell to patients.

Fondaparinux sodium Chemical Structure

Fondaparinux sodium Chemical Structure

CAS No. : 114870-03-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
USD 300 In-stock
Solution
10 mM * 1 mL in Water USD 300 In-stock
Solid
1 mg USD 43 In-stock
5 mg USD 92 In-stock
10 mg USD 158 In-stock
25 mg USD 343 In-stock
50 mg USD 607 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

IC50 & Target

Factor Xa[1]

In Vitro

Fondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. For Fondaparinux, its IC50 values (anti-Xa IU/ml) are 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug does not affect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function or aggregation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1728.08

Formula

C31H43N3Na10O49S8

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H](O)[C@@H]1O[C@](O[C@H](COS(=O)(O[Na])=O)[C@@H](O)[C@@H]2O)([H])[C@@H]2NS(=O)(O[Na])=O)[C@](O[C@@H]1C(O[Na])=O)([H])O[C@H]([C@H](O[C@@H]3O[C@]([C@@H]4O)([H])[C@@H](O[C@@H](O[C@]([C@@H]5O)([H])[C@H](O[C@H](OC)[C@@H]5NS(=O)(O[Na])=O)COS(=O)(O[Na])=O)[C@@H]4OS(=O)(O[Na])=O)C(O[Na])=O)COS(=O)(O[Na])=O)[C@@H]([C@H]3NS(=O)(O[Na])=O)OS(=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (72.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5787 mL 2.8934 mL 5.7868 mL
5 mM 0.1157 mL 0.5787 mL 1.1574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (57.87 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5787 mL 2.8934 mL 5.7868 mL 14.4669 mL
5 mM 0.1157 mL 0.5787 mL 1.1574 mL 2.8934 mL
10 mM 0.0579 mL 0.2893 mL 0.5787 mL 1.4467 mL
15 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9645 mL
20 mM 0.0289 mL 0.1447 mL 0.2893 mL 0.7233 mL
25 mM 0.0231 mL 0.1157 mL 0.2315 mL 0.5787 mL
30 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.4822 mL
40 mM 0.0145 mL 0.0723 mL 0.1447 mL 0.3617 mL
50 mM 0.0116 mL 0.0579 mL 0.1157 mL 0.2893 mL
60 mM 0.0096 mL 0.0482 mL 0.0964 mL 0.2411 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fondaparinux sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fondaparinux sodium
Cat. No.:
HY-B0597
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