R1663
R1663 is a factor Xa inhibitor with anticoagulant activity. R1663 does not affect bleeding time. The pharmacodynamic effects (such as inhibition of thrombin generation) and plasma concentrations of R1663 are dose-dependent. R1663 prolongs clotting time in a concentration-dependent manner and inhibits the peak height of thrombin generation and endogenous thrombin potential.
For research use only. We do not sell to patients.
- CAS No.: 865451-66-7
- Formula: C24H21ClF3N5O3
- Molecular Weight:519.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J82 | IC50 |
840 nM
Compound: 27
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Ex vivo anticoagulation activity in human whole blood assessed as inhibition of J82 cells expressing tissue factor-induced platelet aggregation
Ex vivo anticoagulation activity in human whole blood assessed as inhibition of J82 cells expressing tissue factor-induced platelet aggregation
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[PMID: 20650636] |
Chemical Information
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CAS No. 865451-66-7
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Molecular Weight 519.90
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Formula C24H21ClF3N5O3
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SMILES
O=C([C@H]1CN(CC(F)F)C[C@@H]1C(NC2=CC=C(N3C=CC=CC3=O)C=C2F)=O)NC4=NC=C(Cl)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R1663 Related Classifications
HY-19517 Related Classifications
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