Ganglioside+GM1

By Targets:	Apoptosis (2) Autophagy (2) Biochemical Assay Reagents (6) Drug Derivative (1) Endogenous Metabolite (3) ERK (2) Fluorescent Dye (1) Glycosidase (7) iGluR (2) Isotope-Labeled Compounds (2) Trk Receptor (3)
By Research Areas:	Cancer (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10546

*Ganglioside GM1*	iGluR Trk Receptor ERK Apoptosis Autophagy	Neurological Disease
Ganglioside GM1 is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and *ERK1/2, and inhibiting oxidative stress and cell apoptosis* and autophagy. Ganglioside GM1 can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease ^[1] .

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Biochemical Assay Reagents	Others
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts ^[1].

HY-N10546A

Ganglioside GM1 (bovine) ammonium	iGluR Trk Receptor ERK Apoptosis Autophagy	Neurological Disease
Ganglioside GM1 (bovine) ammonium is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 (bovine) ammonium exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and *ERK1/2, and inhibiting oxidative stress and cell apoptosis* and autophagy. Ganglioside GM1 (bovine) ammonium can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease ^[1] .

HY-P10529

Ganglioside GM1-binding peptide p3	Trk Receptor	Infection
Ganglioside GM1-binding peptide p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of *GM1* ganglioside. The dynamic transformation of Ganglioside GM1-binding peptide p3 may play an important role in the function of *GM1* as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 can be used to study the interaction between *GM1* and its ligands ^[1].

HY-W714151

Ganglioside ga1 Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b	Biochemical Assay Reagents	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses ^[1].

HY-171936

Ganglioside GM1 ammonium GM1 (d18:1/C18:0) ammonium; C18 Ganglioside GM1 (d18:1/18:0) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease ^[1] .

HY-152000S

*C18 Ganglioside GM1-d3 ammonium*	Isotope-Labeled Compounds	Others
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) ^[1].

HY-175074

*C3 BODIPY Ganglioside GM1* (d18:1/3:0) ammonium**	Fluorescent Dye	Others
C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium is a fluorescently labeled GM1 ganglioside probe. C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium can be used as a probe in biological experiments ^[1].

HY-171941A

*C24:1 Ganglioside GM1* (d18:1/24:1) ammonium** C24:1-GM1 ammonium	Endogenous Metabolite	Neurological Disease
C24:1 Ganglioside GM1 (d18:1/24:1) (ammonium) is a monosialylated ganglioside that contains nervonic acid.

HY-171941

*C24:1 Ganglioside GM1* (d18:1/24:1)** C24:1-GM1	Biochemical Assay Reagents	Neurological Disease
C24:1 Ganglioside GM1 (d18:1/24:1) (C24:1-GM1) is a monosialylated ganglioside that contains nervonic acid.

HY-165650

*C16 Ganglioside GM1* (d18:1/16:0)** C16-GM1; N-Hexadecaoyl (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1	Others	Infection
C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) is a member of the ganglioside family containing saturated C16:0 acyl chains. C16 Ganglioside GM1 (d18:1/16:0) serves as a functional receptor for Cholera toxin (HY-P1446) B subunit, while showing reduced efficiency in both transcytosis and retrograde pathways. C16 Ganglioside GM1 (d18:1/16:0) can be used for diarrheal diseases research ^[1].

HY-165650A

*C16 Ganglioside GM1* (d18:1/16:0) ammonium** C16-GM1 ammonium; N-Hexadecaoyl (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1 ammonium	Endogenous Metabolite	Infection
C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) ammonium is a member of the ganglioside family containing saturated C16:0 acyl chains. C16 Ganglioside GM1 (d18:1/16:0) ammonium serves as a functional receptor for Cholera toxin (HY-P1446) B subunit, while showing reduced efficiency in both transcytosis and retrograde pathways. C16 Ganglioside GM1 (d18:1/16:0) ammonium can be used for diarrheal diseases research ^[1].

HY-165650S

*C16 Ganglioside GM1-d9 (d18:1/16:0) ammonium* C16-GM1-d9 ammonium; N-Hexadecaoyl-d9 (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1 ammonium	Isotope-Labeled Compounds	Others
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) ^[1].

HY-P2869J

β-Galactosidase, Kluyveromyces lactis	Biochemical Assay Reagents	Metabolic Disease
β-Galactosidase, Kluyveromyces lactis is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. SubstRates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E70890

β-Galactosidase Mutein, E. coli	Glycosidase	Metabolic Disease
β-Galactosidase Mutein, E. coli is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71027

β-Galactosidase-biotin labeled, Escherichia coli	Biochemical Assay Reagents	Metabolic Disease
β-Galactosidase-biotin labeled, Escherichia coli is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. SubstRates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71299

β-Galactosidase 42A, Bifidobacterium longum	Glycosidase	Others
β-Galactosidase 42A, Bifidobacterium longum (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71299B

β-Galactosidase 42A, Thermotoga maritima	Glycosidase	Others
β-Galactosidase 42A, Thermotoga maritima (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71297

β-Galactosidase 2A, Bacteroides thetaiotaomicron	Glycosidase	Others
β-Galactosidase 2A, Bacteroides thetaiotaomicron (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71296

β-Galactosidase 1A, Sulfolobus solfataricus	Glycosidase	Others
β-Galactosidase 1A, Sulfolobus solfataricus (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-106366

Siagoside	Drug Derivative	Neurological Disease Inflammation/Immunology
Siagoside is an inner ester of Ganglioside GM1 (HY-N10546). Siagoside selectively attenuates morphological and functional striatal impairments induced by transient forebrain ischemia in rats. Siagoside can be used for the research of neurological disease, such as acute cerebral ischemia ^[1].

HY-E71299A

β-Galactosidase 42A, Caldicellulosiruptor saccharolyticus	Glycosidase	Others
β-Galactosidase 42A, Caldicellulosiruptor saccharolyticus (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71298

β-Galactosidase 2B, Bacteroides thetaiotaomicron	Glycosidase	Others
β-Galactosidase 2B, Bacteroides thetaiotaomicron (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

HY-E71025

β 1-4,6-Galactosidase, Jack bean	Biochemical Assay Reagents	Metabolic Disease
β 1-4,6-Galactosidase, Jack bean (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

Cat. No.	Product Name	Type

HY-175074

*C3 BODIPY Ganglioside GM1* (d18:1/3:0) ammonium**	Fluorescent Dyes
C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium is a fluorescently labeled GM1 ganglioside probe. C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium can be used as a probe in biological experiments ^[1].

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Biochemical Assay Reagents
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts ^[1].

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Biochemical Assay Reagents

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10529

Ganglioside GM1-binding peptide p3	Trk Receptor	Infection
Ganglioside GM1-binding peptide p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of *GM1* ganglioside. The dynamic transformation of Ganglioside GM1-binding peptide p3 may play an important role in the function of *GM1* as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 can be used to study the interaction between *GM1* and its ligands ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P990902A

Atigotatug (FUT8-KO) BMS-986012 (FUT8-KO)	Inhibitory Antibodies	Cancer
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10546

*Ganglioside GM1*	Structural Classification Natural Products Animals	iGluR Trk Receptor ERK Apoptosis Autophagy
Ganglioside GM1 is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and *ERK1/2, and inhibiting oxidative stress and cell apoptosis* and autophagy. Ganglioside GM1 can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease ^[1] .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses ^[1].

Cat. No.	Product Name	Chemical Structure

HY-152000S

*C18 Ganglioside GM1-d3 ammonium*
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) ^[1].

HY-165650S

*C16 Ganglioside GM1-d9 (d18:1/16:0) ammonium*
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84938

	Ganglioside GM1 Antibody GM1 ganglioside; Monosialoanglioside; ganglioside GM1.	IHC-P, IHC-F, ICC/IF, FC	Rat
	Ganglioside GM1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Ganglioside GM1.

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Ganglioside+GM1

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