Guanosine kinase

By Targets:	Antibiotic (1) Apoptosis (1) ATP Synthase (1) Bacterial (1) Biochemical Assay Reagents (3) DNA/RNA Synthesis (1) Drug Derivative (1) Fluorescent Dye (1) GLUT (2) HSV (1) Isotope-Labeled Compounds (2) Nucleoside Antimetabolite/Analog (3) PKA (2) PKG (6) Ras (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (2) Metabolic Disease (5) Neurological Disease (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Guanosine (2) Nucleoside Analogs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137677B

GTPγS tetralithium Guanosine 5'-[γ-thio]triphosphate tetralithium	GLUT	Metabolic Disease
GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer .

HY-N0097A

9-β-D-Arabinofuranosylguanine AraG	Drug Derivative	Cancer
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a K_m of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease .

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

HY-17422S1

Acyclovir-d4 Aciclovir-d₄; AcycloGuanosine-d₄	Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic	Infection Cancer
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-148169

2'-Deoxy-L-guanosine	Nucleoside Antimetabolite/Analog	Infection
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-P2881

Nucleoside diphosphate kinase Nucleoside 5′-diphosphate kinase	Biochemical Assay Reagents	Cancer
Nucleoside diphosphate kinase (Nucleoside 5′-diphosphate kinase) belongs to the family of structurally and functionally conserved NDPK (Nucleotide diphosphate kinase) enzymes. Nucleoside diphosphate kinase catalyzes the reversible transfer of γ-phosphates between nucleoside di-(NDP) and triphosphates (NTP) through ping-pong bi-bi reaction kinetics. Nucleoside diphosphate kinase is the essential housekeeping proteins that produces CTP (cytidine triphosphate) for lipid syntheses, UTP (Uridine triphosphate) for polysaccharide syntheses, and GTP (guanosine triphosphate) for protein syntheses, signal transduction, and microtubules polymerization .

HY-137108

Sp-8-pCPT-cGMPS	PKA PKG	Neurological Disease
Sp-8-pCPT-cGMPS is a potent *cyclic guanosine* monophosphate-gated channel agonist and a lipophilic activator of protein kinase G (types I α, I β, and II) and protein kinase A** type II with excellent cell membrane permeability and phosphodiesterase stability. Sp-8-pCPT-cGMPS can be used to study the role of cGMP in neural plasticity and synaptic transmission .

HY-134263

8-Br-cAMP-AM	PKA Ras	Cardiovascular Disease
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .

HY-130530

AP-C5	Biochemical Assay Reagents	Metabolic Disease
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153540

AP-C4	PKG	Others
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .

HY-153541

AP-C7	PKG	Others
AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .

HY-153539

AP-C3	PKG	Others
AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .

HY-153537

AP-C1	PKG	Others
AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .

HY-153542

AP-C6	PKG	Others
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .

HY-E70441

**Guanosine kinase**	Biochemical Assay Reagents	Others
Guanosine kinase can be used to catalyze the formation of GMP from ATP and guanosine .

HY-153538

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2 .

HY-134311

8-NBD-cGMP	Fluorescent Dye	Others
8-NBD-cGMP is a fluorescent analog of cyclic guanosine monophosphate and a potent, membrane-permeable, fluorescent activator of cGMP-dependent protein kinase isozymes I α and I β. 8-NBD-cGMP is barely fluorescent in aqueous solution but fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites

HY-10250S1

Triciribine phosphate-d3 TCN-P-d₃	Isotope-Labeled Compounds ATP Synthase	Metabolic Disease
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-114265

Guanosine 3',5'-bisdiphosphate ppGpp	Nucleoside Antimetabolite/Analog	Others
Guanosine 3',5'-bisdiphosphate (ppGpp) plays a pivotal role in the regulation of GTP biosynthesis in chloroplasts through specific inhibition of plastid/mitochondrial guanylate kinase activity .

HY-137677

GTP-γ-S Guanosine 5'-[γ-thio]triphosphate	GLUT	Metabolic Disease
GTPγS (Guanosine 5'-[γ-thio]triphosphate) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS to couple with G- protein α, to study its effect on kinase activity. GTPγS acts as a component of lysis buffer .

Cat. No.	Product Name	Type

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Biochemical Assay Reagents
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114265

Guanosine 3',5'-bisdiphosphate ppGpp	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Guanosine 3',5'-bisdiphosphate (ppGpp) plays a pivotal role in the regulation of GTP biosynthesis in chloroplasts through specific inhibition of plastid/mitochondrial guanylate kinase activity .

Cat. No.	Product Name	Chemical Structure

HY-17422S1

Acyclovir-d4
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-10250S1

Triciribine phosphate-d3
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

Triciribine phosphate-d3

Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

Cat. No.	Product Name		Classification

HY-130530

AP-C5		Alkynes
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-148169

2'-Deoxy-L-guanosine		Nucleoside Analogs Guanosine
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-E70441

**Guanosine kinase**		Nucleoside Analogs Guanosine
Guanosine kinase can be used to catalyze the formation of GMP from ATP and guanosine .

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