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AP-C5 

Cat. No.: HY-130530
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AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease.

For research use only. We do not sell to patients.

AP-C5 Chemical Structure

AP-C5 Chemical Structure

CAS No. : 2234272-10-5

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Description

AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease[1].

IC50 & Target

pIC50: 7.2 (cGKII)[1]

In Vitro

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue[1].
AP-C5 potentiates cAMP signaling by PDE inhibition[1].
AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum[1].

Molecular Weight

275.31

Formula

C₁₆H₁₃N₅

CAS No.

2234272-10-5

SMILES

C#CCNC1=NC=CC(C2=CC=C(N3C=CN=C3)C=C2)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AP-C5OthersPKGGMPdiarrhealInhibitorinhibitorinhibit

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