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HCoV229E

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By Targets:	Apoptosis (2) Calcium Channel (1) HIV (1) PI3K (1) PROTACs (1) SARS-CoV (8) Sodium Channel (1) Virus Protease (2)
By Research Areas:	Cancer (3) Infection (8)

9

Inhibitors & Agonists

1

Natural
Products

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132169

HCoV-229E-IN-1

SARS-CoV Infection

HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC₅₀ of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively .

Thapsigargin Maximum Cited Publications 51 Publications Verification	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

Mpro inhibitor N3	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC₅₀ value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59 .

Vps34-IN-2 2 Publications Verification	PI3K SARS-CoV	Cancer
Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC₅₀s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively . Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC₅₀ of 3.1 μM), *HCoV-229E* (IC₅₀ of 0.7 μM) and *HCoV-OC43* .

SARS-CoV-2-IN-53	SARS-CoV	Infection
ARS-CoV-2-IN-53 (Compd 5d) can inhibit the replication of SARS-CoV-2 with an EC₅₀ value of 14.3 μM. ARS-CoV-2-IN-5 shows significant antiviral activity against human coronavirus 229E (HCoV-229E) .

Mpro inhibitor N3 hemihydrate	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC₅₀ of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC₅₀ of 4.0 μM, 8.8 μM, and 2.7 μM, respectively .

BPR3P0128	SARS-CoV	Infection
BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC₅₀ for SARS-CoV-2 and HCoV-229E are 0.62 µM and 0.14 µM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077) .

5-(N,N-Hexamethylene)-amiloride 1 Publications Verification Hexamethylene amiloride; HMA	Sodium Channel HIV Apoptosis	Infection Cancer
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na ⁺/H ⁺ exchanger inhibitor, which decreases the intracellular pH (pH_i) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC₅₀s of 3.91 μM and 1.34 μM, respectively .

PROTAC SARS-CoV-2 Mpro degrader-2	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 M ^pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC₅₀ = 10.8 μM), HCoV-OC43 (EC₅₀ = 1.6 μM) and HCoV-229E (EC₅₀ = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC₅₀ of 0.89 μM .

Species:	Virus (3)
Tag:	His (3)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	HCoV-229E Nucleoprotein/NP Protein (NP_073556, His) Human coronavirus (HCoV-229E) Nucleoprotein / NP Protein (His)	Virus	E. coli
	H-CoV Nucleoprotein (NP, N) is a homodimer with nonspecific binding activity toward nucleic acids. NP packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly, enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication through its interactions with the viral genome and membrane protein M. HCoV-229E Nucleoprotein/NP Protein (NP_073556, His) is the recombinant Virus-derived HCoV-229E Nucleoprotein/NP protein, expressed by E. coli , with N-His labeled tag. The total length of HCoV-229E Nucleoprotein/NP Protein (NP_073556, His) is 389 a.a., with molecular weight of ~44.43 KDa.

	HCoV-229E Spike/S Protein (APT69883, sf9, His) Human coronAvirus (HCoV-229E) Spike Protein (S1+S2 ECD, His)	Virus	Sf9 insect cells
	Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses with the largest genomes known among RNA viruses. The CoVs S-protein mediates receptor binding and fusion of the viral and host cell membranes. HCoV-229E is an alpha-coronaviruse that uses different host proteins as receptors.In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation. HCoV-229E exploits trypsin, cathepsin L and TMPRSS2 to complete the fusion activation mediated by the S protein. HCoV-229E Spike/S Protein (APT69883, sf9, His) is the recombinant Virus-derived HCoV-229E Spike/S protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of HCoV-229E Spike/S Protein (APT69883, sf9, His) is 1100 a.a., with molecular weight of ~122.1 KDa.

	HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) Human coronAvirus (HCoV-229E) Spike/S1 Protein (S1 Subunit, His)	Virus	HEK293
	Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses with the largest genomes known among RNA viruses. The CoVs S-protein mediates receptor binding and fusion of the viral and host cell membranes. HCoV-229E is an alpha-coronaviruse that uses different host proteins as receptors.In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation. HCoV-229E exploits trypsin, cathepsin L and TMPRSS2 to complete the fusion activation mediated by the S protein. HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) is the recombinant Virus-derived HCoV-229E Spike/S1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HCoV-229E Spike/S1 Protein (APT69883, HEK293, His) is 521 a.a., with molecular weight of ~58.3 KDa.

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