1. Membrane Transporter/Ion Channel
    Anti-infection
    Apoptosis
  2. Sodium Channel
    HIV
    Apoptosis
  3. 5-(N,N-Hexamethylene)-amiloride

5-(N,N-Hexamethylene)-amiloride (Synonyms: Hexamethylene amiloride; HMA)

Cat. No.: HY-128067 Purity: >98.0%
Handling Instructions

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.

For research use only. We do not sell to patients.

5-(N,N-Hexamethylene)-amiloride Chemical Structure

5-(N,N-Hexamethylene)-amiloride Chemical Structure

CAS No. : 1428-95-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2].

IC50 & Target

Na+/H+ exchanger[1]
EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]

Clinical Trial
Molecular Weight

311.77

Formula

C₁₂H₁₈ClN₇O

CAS No.

1428-95-1

SMILES

O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Product Name:
5-(N,N-Hexamethylene)-amiloride
Cat. No.:
HY-128067
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