2. PROTAC Anti-infection
  3. PROTACs SARS-CoV
  4. PROTAC SARS-CoV-2 Mpro degrader-2

PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM.

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PROTAC SARS-CoV-2 Mpro degrader-2

PROTAC SARS-CoV-2 Mpro degrader-2 Chemical Structure

CAS No. : 3057294-32-0

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PROTAC SARS-CoV-2 Mpro degrader-2 Related Antibodies

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Description

PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM[1].

Cellular Effect
Cell Line Type Value Description References
Calu-3 CC50
> 125 μM
Compound: 6
Cytotoxicity against human Calu-3 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human Calu-3 cells incubated for 72 hrs by MTT assay
[PMID: 38394929]
MRC5 CC50
> 125 μM
Compound: 6
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38394929]
Vero CC50
> 125 μM
Compound: 6
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38394929]
Molecular Weight

910.52

Formula

C48H56ClN7O7S
CAS No.
SMILES

ClC1=CC=C(C(N2C3=CC=C(OC)C=C3C(CC(N4CCN(CC4)CC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)C(C)(C)C)=O)=O)=C2C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SARS-CoV-2 Mpro degrader-2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SARS-CoV-2 Mpro degrader-23057294-32-0PROTACsSARS-CoVSARS coronavirusantiviralSARS-CoV-2HCoV-OC43HCoV-229ECoVsCalu-3Inhibitorinhibitorinhibit

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