2. Anti-infection
  3. SARS-CoV
  4. BPR3P0128

BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 µM and 0.14 µM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077).

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BPR3P0128 Chemical Structure

BPR3P0128 Chemical Structure

CAS No. : 1345406-09-8

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BPR3P0128 Related Antibodies

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Description

BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 µM and 0.14 µM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077)[1].

In Vitro

BPR3P0128 (10 μM, 24 hours) can effectively inhibit the replication of SARS-CoV-2 in human lung cancer cell line Calu-3 and reduce the expression of cytokines induced by viral infection[1].
BPR3P0128 (1 μM, 10 μM) has comprehensive activity against coronavirus and can effectively inhibit different SARS-CoV-2 (including α, β, γ, δ, and plasmid strains) variants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPR3P0128 Related Antibodies

RT-PCR[1]

Cell Line: Vero E6 cells containing SARS-CoV-2 virus
Concentration: 10 μM
Incubation Time: 0-24h
Result: Significantly decreased the mRNA expression levels of CXCL10, IL-6, TNF-α and INF-β.

Western Blot Analysis[1]

Cell Line: Vero E6 cells containing SARS-CoV-2 virus
Concentration: BPR3P0128: 1 μM, 2 μM; Remdesivir: 4 μM, 8 μM
Incubation Time: 24h
Result: And Remdesivir synergistically inhibited NP expression more significantly.

Western Blot Analysis[1]

Cell Line: HEK293T cell-based RdRp reporter model
Concentration: BPR3P0128: 0.1 μM, 1 μM, 10 μM; Remdesivir: 1 μM, 10 μM, 100 μM
Incubation Time: 24h
Result: Inhibited the activity of SARS-CoV-2 RdRp, but did not decrease the expression level of nsp12.
In Vivo


Pharmacokinetic Analysis in Sprague–Dawley rats Model[1]

Route Dose (mg/kg) Cl (mL•min/kg) t1/2 (h) F (%)
i.v. 0.01 1.3 / /
p.o. 0.01 / 8.1 78.7%

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

436.30

Formula

C22H18BrN3O2
CAS No.
SMILES

O=C(O)C1=CC(C2=C(C)N(C3=CC(C)=CC=C3C)N=C2)=NC4=CC=C(Br)C=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BPR3P0128 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPR3P01281345406-09-8SARS-CoVSARS coronavirusHydroxychloroquineSARS-CoV-2HCoV-229EAntiviralRemdesivirSARS-CoV-2 variantsInhibitorinhibitorinhibit

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