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Results for "

Inositol triphosphate receptor

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W009724
    2-Aminoethyl diphenylborinate
    70+ Cited Publications

    2-APB

    		 Calcium Channel TRP Channel CRAC Channel Cardiovascular Disease Inflammation/Immunology
    2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca 2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .
    2-Aminoethyl diphenylborinate
  • HY-17397
    Strontium Ranelate
    2 Publications Verification

    Distrontium renelate; S12911

    		 CaSR Metabolic Disease
    Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .
    Strontium Ranelate
  • HY-163171
    ARN11391

    		Chloride Channel Neurological Disease
    ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia .
    ARN11391
  • HY-175383
    D-myo-Inositol-1,2,6-triphosphate sodium

    Ins(1,2,6)-P3; 1,2,6-IP3

    		 Calcium Channel Others
    D-myo-Inositol-1,2,6-triphosphate (sodium) is one of the members in inositol phosphate family of second messengers that play an important role in transmitting cellular signals. D-myo-Inositol-1,2,6-triphosphate (sodium) can open calcium channels and increase intracellular calcium upon binding to its receptor on the endoplasmic reticulum .
    D-myo-Inositol-1,2,6-triphosphate sodium
  • HY-175070
    D-myo-Inositol-2,4,5-triphosphate sodium salt

    Ins(2,4,5)P3 sodium salt; 2,4,5-IP3 sodium salt

    		 Calcium Channel Metabolic Disease
    D-myo-Inositol-2,4,5-triphosphate (Ins(2,4,5)P3) (sodium salt) is a second messenger produced in cells by phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can open calcium channels and increase intracellular calcium upon binding to its receptors on the endoplasmic reticulum. D-myo-Inositol-2,4,5-triphosphate (sodium salt) also acts as a partial agonist at rat hepatic IP3 receptors. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can be studied in research on calcium ions signaling pathway .
    D-myo-Inositol-2,4,5-triphosphate sodium salt
  • HY-17397R
    Strontium Ranelate (Standard)

    Distrontium renelate (Standard); S12911 (Standard)

    		 Reference Standards CaSR Metabolic Disease
    Strontium Ranelate (Standard) is the analytical standard of Strontium Ranelate. This product is intended for research and analytical applications. Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .
    Strontium Ranelate (Standard)
  • HY-137603
    Uridine-5'-O-3-thiotriphosphate

    UTPγS

    		 P2Y Receptor Metabolic Disease
    Uridine-5'-O-(3-thiotriphosphate) (UTPγS), a stable analogue of Uridine triphosphate (UTP) (HY-107372), is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O-(3-thiotriphosphate) stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM) .
    Uridine-5'-O-3-thiotriphosphate
  • HY-181471
    D-myo-Inositol-3,4,5-triphosphate hexasodium

    		Calcium Channel Drug Derivative Others
    D-myo-Inositol-3,4,5-triphosphate hexasodium is an inositol (HY-B1411) derivative, a subtype-selective IP3 receptor ligand, with Kd values of 31706 nM, 3019 nM and 11145 nM for rat type 1, type 2 and type 3 receptors, respectively .
    D-myo-Inositol-3,4,5-triphosphate hexasodium
  • HY-137603A
    Uridine-5'-O-3-thiotriphosphate tetrasodium

    UTPγS tetrasodium

    		 P2Y Receptor Neurological Disease Metabolic Disease
    Uridine-5'-O-(3-thiotriphosphate) (UTPγS) tetrasodium, a stable analogue of Uridine triphosphate (UTP) (HY-107372), is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O-(3-thiotriphosphate) tetrasodium stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM) .
    Uridine-5'-O-3-thiotriphosphate tetrasodium

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