LRMP Antibody (YA5975)

Cat. No.: HY-P86283: Data Sheet User Guide for Antibodies
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LRMP Antibody (YA5975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRMP.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LRMP Antibody (YA5975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRMP.

Host

Rabbit

Clonality

Monoclonal

Molecular Weight

Observed band size: 61 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q12912

Gene ID

4033 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-5000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-300
ICC	ICC/IF: 1:100-300
FC 1	100-300

Purity	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)

Subcellular Localization：Cytoplasm; Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Nucleus envelope; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Chromosome

Expression：
Tissue_specificity:Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles

Isoforms & Post-Translational Modification：Q12912 has 2 isomers: Q12912-1: 62122 Da (predicted); Q12912-2: 56213 Da (predicted).
The removal of the C-terminal lumenal domain occurs by proteolytic processing

Subunit：Interacts (via coiled-coil domain) with ITPR3. Interacts with SUN1 and SUN2. Interacts with microtubules. Interacts with HCN4; regulates HCN4 channel activity (By similarity)

Synonyms

IRAG2; JAW1; LRMP; Inositol 1,4,5-triphosphate receptor associated 2 ; Lymphoid-restricted membrane protein; Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2];

Documentation

User Guide for Antibodies (1077 KB)