LRMP Antibody (YA5975)
(Synonyms: IRAG2; JAW1; LRMP; Inositol 1,4,5-triphosphate receptor associated 2 ; Lymphoid-restricted membrane protein; Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]; )LRMP Antibody (YA5975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRMP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC
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FC 1
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:100-300 | ICC/IF: 1:100-300 | 100-300 |
Product Details
LRMP Antibody (YA5975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRMP.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 61 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Versand
Shipping with blue ice.
Background
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Function
LRMP plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity
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Subcellular Localization
Cytoplasm; Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Nucleus envelope; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Chromosome
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Expression
Tissue_specificity:Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles -
Isoforms & Post-Translational Modification
Q12912 has 2 isomers: Q12912-1: 62122 Da (predicted); Q12912-2: 56213 Da (predicted).
The removal of the C-terminal lumenal domain occurs by proteolytic processing -
Subunit
Interacts (via coiled-coil domain) with ITPR3. Interacts with SUN1 and SUN2. Interacts with microtubules. Interacts with HCN4; regulates HCN4 channel activity (By similarity)
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SwissProt ID
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Synonyms
IRAG2; JAW1; LRMP; Inositol 1,4,5-triphosphate receptor associated 2 ; Lymphoid-restricted membrane protein; Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2];
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