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Results for "

MCH1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (1) Drug Derivative (1) EGFR (1) Endogenous Metabolite (1) MCHR1 (GPR24) (12) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Endocrinology (3) Metabolic Disease (8) Neurological Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1205A

MCH(human, mouse, rat) TFA 1 Publications Verification Melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human *MCH-1R* and *MCH-2R, respectively; its functional EC₅₀* values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions ^[1] .

HY-111398

ALB-127158(a) 1 Publications Verification	MCHR1 (GPR24)	Metabolic Disease Endocrinology
ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH₁) receptor antagonist.

HY-W039283

MCH-1 antagonist 2	MCHR1 (GPR24)	Neurological Disease Cancer
MCH-1 antagonist 2 (l-BROMO-2,4-DIFLUORO-5-NITROBEN-ZENE) is a melanin concentrating hormone-1 (MCH1) receptor-selective 4-aryl piperidine. MCH-1 antagonist 2 can be used for the research of depression, anxiety, obesity, urge incontinence, urinary incontinence, major depression, bipolar disorder, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, acute stress disorder, urinary frequency, urinary urgency, nocturia, enuresis, bulimia, bulimia nervosa, anorexia nervosa, major depressive disorder, dysthymic disorder, bipolar 1 and 2 disorders, schizoaffective disorder, cognitive disorders with depressed mood, personality disorders, insomnia, hypersomnia, narcolepsy, circadian rhythm sleep disorder, nightmare disorder, sleep terror disorder, sleepwalking disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, overactive bladder ^[1].

HY-100331

MCH-1 antagonist 1	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM.

HY-107624

ATC0175 1 Publications Verification	MCHR1 (GPR24)	Neurological Disease
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders ^[1].

HY-P1205

MCH(human, mouse, rat) 1 Publications Verification Melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human *MCH-1R* and *MCH-2R, respectively; its functional EC₅₀* values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions ^[1] .

HY-P3155

Ac-hMCH(6-16)-NH2	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC₅₀ values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R ^[1].

HY-U00353

MCHR1 antagonist 1	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 1 is a selective antagonist of *melanin concentrating hormone-1 (MCH1) receptor, with a K_b* of 1 nM and a K_i of 4 nM at human MCH1, and may be used to reduce the body mass.

HY-11084

SNAP-7941	Endogenous Metabolite	Neurological Disease
SNAP-7941 is a selective antagonist with anxiolytic, antidepressant and appetite suppressant activities. SNAP-7941 showed promising biological activity in initial animal studies. SNAP-7941 targets the melanin concentrating hormone receptor MCH1 and has significant inhibitory potential. SNAP-7941 was shown to inhibit the centrally induced MCH-induced drinking effect in in vivo studies ^[1].

HY-181551

RGH-706	MCHR1 (GPR24)	Metabolic Disease
RGH-706 is an orally active, blood-brain barrier-permeable, selective *MCH1* receptor antagonist with an IC₅₀ of 6.2 nM against hMCHR1. RGH-706 shows no antagonistic activity against hMCH2 receptors. RGH-706 improves obesity. RGH-706 can be used in research related to obesity and Prader-Willi syndrome ^[1].

HY-107623

*TC-MCH* 7c**	MCHR1 (GPR24)	Metabolic Disease
TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable *MCH₁R* antagonist with an IC₅₀ of 5.6 nM for hMCH₁R ^[1]. TC-MCH 7c has K_is of 3.4 nM and 3.0 nM of human and mouse MCH₁R, respectively .

HY-RS24346

Cap1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cap1 Rat Pre-designed siRNA Set A Cap1 Rat Pre-designed siRNA Set A

HY-111072

ADS103317	Drug Derivative EGFR MCHR1 (GPR24)	Cancer
ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits *MCH-1R. Afatinib is an EGFR* inhibitor. ADS103317 can be used in research related to non-small cell lung cancer ^[1] .

HY-107624R

ATC0175 (Standard)	Reference Standards MCHR1 (GPR24)	Neurological Disease
ATC0175 (Standard) is the analytical standard of ATC0175 (HY-107624). This product is intended for research and analytical applications. ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P1205A

MCH(human, mouse, rat) TFA 1 Publications Verification Melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human *MCH-1R* and *MCH-2R, respectively; its functional EC₅₀* values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions ^[1] .

HY-P1205

MCH(human, mouse, rat) 1 Publications Verification Melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human *MCH-1R* and *MCH-2R, respectively; its functional EC₅₀* values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions ^[1] .

HY-P3155

Ac-hMCH(6-16)-NH2	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC₅₀ values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R ^[1].

Cap1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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