1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. MCHR1 (GPR24)
    Cytochrome P450
  3. MCH-1 antagonist 1

MCH-1 antagonist 1 

Cat. No.: HY-100331
Handling Instructions

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

For research use only. We do not sell to patients.

MCH-1 antagonist 1 Chemical Structure

MCH-1 antagonist 1 Chemical Structure

CAS No. : 1039825-68-7

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Description

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

IC50 & Target[1]

MCH-1

2.6 nM (Ki)

CYP3A4

10 μM (IC50)

In Vitro

MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].

In Vivo

MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1].

Molecular Weight

414.50

Formula

C₂₅H₂₆N₄O₂

CAS No.

1039825-68-7

SMILES

O=C1C=C(OCC2=CC=CC=C2)C=CN1C3=CC4=C(N(CCN5CCCC5)N=C4)C=C3

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MCH-1 antagonist 1
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HY-100331
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