2. MCH-1 antagonist 1

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

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MCH-1 antagonist 1 Chemical Structure

MCH-1 antagonist 1 Chemical Structure

CAS No. : 1039825-68-7

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MCH-1 antagonist 1 Related Antibodies

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Description

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

IC50 & Target

Ki: 2.6 nM (MCH-1)[1]
IC50: 10 μM (CYP3A4)[1]
In Vitro

MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCH-1 antagonist 1 Related Antibodies
In Vivo

MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

414.50

Formula

C25H26N4O2
CAS No.
SMILES

O=C1C=C(OCC2=CC=CC=C2)C=CN1C3=CC4=C(N(CCN5CCCC5)N=C4)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCH-1 antagonist 11039825-68-7Inhibitorinhibitorinhibit

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MCH-1 antagonist 1
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HY-100331
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