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Melia toosendan Sieb. et Zucc.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (3) Reference Standards (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0263

Toosendanin 5+ Cited Publications	Others	Inflammation/Immunology
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

HY-N18150

12-O-Methylvolkensin	Others	Cancer
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

HY-N0263R

Toosendanin (Standard)	Reference Standards Others	Inflammation/Immunology
Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

HY-N18210

12-O-Ethyl-1-deacetylnimbolinin B	Others	Others
12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc .

HY-N18172

Meliatoosenin K	Drug Derivative	Others
Meliatoosenin K is a trichilinin-type limonoid found in the fruits of Melia toosendan .

HY-N18044

Toosendanal	Drug Derivative	Others
Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al. .

HY-N18115A

Toosendansin A	Drug Derivative	Cancer
Toosendansin A is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. Toosendansin A can be used for the research of leukemia, stomach cancer, breast cancer .

HY-N18124

1-O-Tigloyl-1-O-debenzoylohchinal	Others	Neurological Disease
1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases .

Toosendanin 5+ Cited Publications	Triterpenes Classification of Application Fields Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Inflammation/Immunology Disease Research Fields Source Classification	Others
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

12-O-Methylvolkensin	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

Toosendanin (Standard)	Triterpenes Structural Classification Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Source Classification	Reference Standards Others
Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

12-O-Ethyl-1-deacetylnimbolinin B	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc .

Meliatoosenin K	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Drug Derivative
Meliatoosenin K is a trichilinin-type limonoid found in the fruits of Melia toosendan .

Toosendanal	Structural Classification Melia azedarach Linn. Ketones, Aldehydes, Acids Plants Meliaceae Source Classification	Drug Derivative
Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al. .

Toosendansin A	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	Drug Derivative
Toosendansin A is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. Toosendansin A can be used for the research of leukemia, stomach cancer, breast cancer .

1-O-Tigloyl-1-O-debenzoylohchinal	Structural Classification Melia azedarach Linn. Ketones, Aldehydes, Acids Plants Meliaceae Source Classification	Others
1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Melia toosendan Sieb. et Zucc.

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