Toosendansin A
Toosendansin A is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. Toosendansin A can be used for the research of leukemia, stomach cancer, breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1802166-79-5
- Formula: C37H48O9
- Molecular Weight:636.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Toosendansin A (Compound 1) (500 μg/mL) shows no obvious anti-TMV activity[1].
Toosendansin A (10-5 M) shows no obvious protective effect on H2O2-induced damage of SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1802166-79-5
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Molecular Weight 636.77
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Formula C37H48O9
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SMILES
C[C@@]12[C@](O[C@@]3([H])C2=C([C@H](C4=COC=C4)C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)([C@H](C[C@H]([C@]6(CO5)C)OC(/C(C)=C/C)=O)OC(/C(C)=C/C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Toosendansin A Related Classifications
HY-N18115A Related Classifications
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