Triterpenoids with anti-tobacco mosaic virus activities from Melia toosendan

  • Fitoterapia. 2014 Sep:97:204-10. doi: 10.1016/j.fitote.2014.06.010.
Lin Chen  1 ,  Jian-Xin Zhang  2 ,  Bin Wang  2 ,  Shu-Zhen Mu  3 ,  Xiao-Jiang Hao  2
Affiliations
  • 1. College of Pharmacy, Guizhou University, Guiyang 550025, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
  • 2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
  • 3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. Electronic address: [email protected].
PMID: 24972348 DOI: 10.1016/j.fitote.2014.06.010
Abstract

Four new triterpenoids, named Toosendansins A-D (1-4), along with nine known ones (5-13) were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their structures were established on the basis of spectroscopic data. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells. Compound 7 showed evident anti-TMV activity. Compounds 2 and 9 exhibited modest protection against H2O2-induced damage of SH-SY5Y cells.

Keywords
Anti-tobacco mosaic virus activities; Limonoids; Melia toosendan; Triterpenoids.
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